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Titolo:
VAV LINKS ANTIGEN-RECEPTOR SIGNALING TO THE ACTIN CYTOSKELETON
Autore:
FISCHER KD; TEDFORD K; PENNINGER JM;
Indirizzi:
UNIV WURZBURG,MSZ INST MED STRAHLENKUNDE & ZELLFORSCH,VERSBACHER STR 5 D-97078 WURZBURG GERMANY UNIV TORONTO,AMGEN INST,ONTARIO CANC INST TORONTO ON M5G 2C1 CANADA UNIV TORONTO,DEPT MED BIOPHYS TORONTO ON M5G 2C1 CANADA UNIV TORONTO,DEPT IMMUNOL TORONTO ON M5G 2C1 CANADA
Titolo Testata:
Seminars in immunology
fascicolo: 4, volume: 10, anno: 1998,
pagine: 317 - 327
SICI:
1044-5323(1998)10:4<317:VLASTT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; PROTOONCOGENE PRODUCT VAV; GTP EXCHANGE FACTOR; TYROSINE PHOSPHORYLATION; PHOSPHATIDYLINOSITOL 3-KINASE; HEMATOPOIETIC-CELLS; POSITIVE SELECTION; KINASE ACTIVATION; ALPHA-BETA; RHO-FAMILY;
Keywords:
VAV; GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF); RHO GTPASES; T AND B CELLS; ACTIN CYTOSKELETON; ANTIGEN-RECEPTOR CAPPING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
K.D. Fischer et al., "VAV LINKS ANTIGEN-RECEPTOR SIGNALING TO THE ACTIN CYTOSKELETON", Seminars in immunology, 10(4), 1998, pp. 317-327

Abstract

The haematopoietic-specific Rho-family guanine-nucleotide exchange factor Vav is a regulator of lymphocyte antigen receptor signaling leading to proliferation of B and T cells, generation of the B1 cell lineage and IL-2 production and maturation in T cells. The specific role it plays in these events, however, has not yet been resolved Recent findings suggest that Vav is recruited to activated antigen receptors and requires both tyrosine phosphorylation and the presence of activating phospholipids for catalytic activity towards Rho-family GTPases. Studies from vav-deficient mice show that in response to antigen receptor activation, Vav is not essential for activation of JNK kinase pathways, but is required for actin polymerisation and T cell capping. We discuss Vav function in the light of these new findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:30:09