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Titolo:
CD21 CD35 IN B-CELL ACTIVATION
Autore:
CARROLL MC;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT PATHOL,200 LONGWOOD AVE,D-2538 BOSTON MA 02115
Titolo Testata:
Seminars in immunology
fascicolo: 4, volume: 10, anno: 1998,
pagine: 279 - 286
SICI:
1044-5323(1998)10:4<279:CCIBA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE COMPLEMENT RECEPTOR-1; FOLLICULAR DENDRITIC CELL; GERMINAL CENTER REACTION; T-DEPENDENT ANTIGEN; LYMPHOCYTES-B; IMMUNE-RESPONSE; MONOCLONAL-ANTIBODY; REGULATORY PROTEINS; ACQUIRED-IMMUNITY; TYPE-1 CR-1;
Keywords:
COMPLEMENT RECEPTORS; INNATE IMMUNITY; B CELL CORECEPTOR; CLONAL SELECTION; GERMINAL CENTER B CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Carroll, "CD21 CD35 IN B-CELL ACTIVATION", Seminars in immunology, 10(4), 1998, pp. 279-286

Abstract

The stimulus induced via the B cell receptor is a major factor in determination of the fate of naive B cells resulting in activation, elimination or anergy. The strength of B cell signal transduction is dependent not only on the affinity of antigen binding, but by positive signals via the co-receptor CD21/CD19/Tapa-1. Absence of CD21 expression byB cells results in an impaired humoral response to T-dependent antigens which is characterized by a reduction in B cell follicular retention and germinal center survival. The ligand for CD21 is complement C3d which becomes attached to antigen on activation of the complement system. Thus, the complement system of innate immunity is an important regulator of B lymphocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:07:17