Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CD19 REGULATES B-LYMPHOCYTE RESPONSES TO TRANSMEMBRANE SIGNALS
Autore:
FUJIMOTO M; POE JC; INAOKI M; TEDDER TF;
Indirizzi:
DUKE UNIV,MED CTR,DEPT IMMUNOL,BOX 3010 DURHAM NC 27710
Titolo Testata:
Seminars in immunology
fascicolo: 4, volume: 10, anno: 1998,
pagine: 267 - 277
SICI:
1044-5323(1998)10:4<267:CRBRTT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; PROTEIN-TYROSINE KINASE; LYN-DEFICIENT MICE; HUMORAL IMMUNE-RESPONSE; T-DEPENDENT ANTIGEN; PHOSPHATIDYLINOSITOL 3-KINASE; TRANSDUCTION COMPLEX; CYTOPLASMIC DOMAIN; CA2+ MOBILIZATION; TRANSGENIC MICE;
Keywords:
B LYMPHOCYTE; CD19; IMMUNOGLOBULIN; HUMORAL IMMUNITY; SRC-FAMILY PROTEIN TYROSINE KINASE; VAV;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
M. Fujimoto et al., "CD19 REGULATES B-LYMPHOCYTE RESPONSES TO TRANSMEMBRANE SIGNALS", Seminars in immunology, 10(4), 1998, pp. 267-277

Abstract

CD19 is a component of a cell surface receptor complex that regulatesB lymphocyte responses to transmembrane signals including those generated through the B cell antigen receptor. Studies in mice which lack or overexpress CD19 show that changes in CD19 expression levels have significant effects on B cell development and function. Recent studies suggest that CD19 establishes a Src-family kinase activation loop that amplifies tyrosine phosphorylation of numerous downstream effector molecules including potentially positive and negative regulatory elements. These observations provide an understanding of how CD19 governs the molecular ordering and intensity of signals transduced through multiple B cell receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:34:29