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Titolo:
GLYCOBIOLOGY OF THE OLFACTORY SYSTEM
Autore:
PLENDL J; SINOWATZ F;
Indirizzi:
UNIV MUNICH,INST VET ANAT,VET STR 13 D-80539 MUNICH GERMANY
Titolo Testata:
Acta anatomica
fascicolo: 1-4, volume: 161, anno: 1998,
pagine: 234 - 253
SICI:
0001-5180(1998)161:1-4<234:GOTOS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; RAT NERVOUS-SYSTEM; PHASEOLUS-VULGARIS-LEUCOAGGLUTININ; PARAFASCICULAR THALAMIC NUCLEI; HEPARAN-SULFATE PROTEOGLYCAN; NASAL RESPIRATORY EPITHELIA; SOYBEAN AGGLUTININ BINDING; MEMBRANE-PROTEINS UNIQUE; LECTIN-HISTOCHEMISTRY; VOMERONASAL ORGAN;
Keywords:
OLFACTORY SYSTEM; VOMERONASAL SYSTEM; NEURON; GLYCOCONJUGATE; LECTIN; CELL ADHESION; EXTRACELLULAR MATRIX; DEVELOPMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
187
Recensione:
Indirizzi per estratti:
Citazione:
J. Plendl e F. Sinowatz, "GLYCOBIOLOGY OF THE OLFACTORY SYSTEM", Acta anatomica, 161(1-4), 1998, pp. 234-253

Abstract

The olfactory system is a highly plastic region of the nervous system. Continuous remodeling of neuronal circuits in the olfactory bulb takes place throughout life as a result of constant turnover of primary sensory olfactory neurons in the periphery. Glycoconjugates are very important in olfactory development, regeneration and function. This article deals with different aspects of glycobiology relevant for the olfactory system. Various anatomical? developmental and functional subdivisions of the olfactory system have been labeled with exogenous lectins. The application of reverse lectin histochemistry resulted in the visualization of endogenous lectins, involved in fasciculation of olfactory axons. Numerous glycoproteins, among them members of the immunoglobulin superfamily, the cadherins and integrins as well as different,glycolipids and proteoglycans can act as surface adhesion molecules in the olfactory system. The olfactory-specific form of the sialoglycoprotein neural cell adhesion molecule is implicated in olfactory neuronal and axonal guidance. Glycoconjugates including laminin, fibronectin andproteoglycans are abundant components of the olfactory extracellular matrix, influencing neurite outgrowth and cellular migration. Immunohistochemical labeling has revealed occurrence of the carbohydrate differentiation antigen, playing a role in neurulation and morphogenesis ofthe very early olfactory system. The synaptic vesicle glycoprotein, appearing also early in olfactory development, is used as a marker of olfactory tumors. Finally, membrane and transmembrane glycoconjugates as well as secreted glycoconjugates may act as olfactory receptor molecules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:58:54