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Titolo:
THE IL-1 RECEPTOR-RELATED T1 ANTIGEN IS EXPRESSED ON IMMATURE AND MATURE MAST-CELLS AND ON FETAL BLOOD MAST-CELL PROGENITORS
Autore:
MORITZ DR; RODEWALD HR; GHEYSELINCK J; KLEMENZ R;
Indirizzi:
UNIV ZURICH HOSP,INST PATHOL,DIV CANC RES,DEPT PATHOL,SCHMELZBERGSTR 12 CH-8091 ZURICH SWITZERLAND UNIV ZURICH HOSP,INST PATHOL,DIV CANC RES,DEPT PATHOL CH-8091 ZURICH SWITZERLAND BASEL INST IMMUNOL BASEL SWITZERLAND
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 9, volume: 161, anno: 1998,
pagine: 4866 - 4874
SICI:
0022-1767(1998)161:9<4866:TIRTAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1 RECEPTOR; BONE-MARROW; RESPONSIVE GENE; SIGNAL-TRANSDUCTION; PERIPHERAL-BLOOD; FC-RECEPTORS; KIT-LIGAND; C-KIT; GROWTH; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Moritz et al., "THE IL-1 RECEPTOR-RELATED T1 ANTIGEN IS EXPRESSED ON IMMATURE AND MATURE MAST-CELLS AND ON FETAL BLOOD MAST-CELL PROGENITORS", The Journal of immunology (1950), 161(9), 1998, pp. 4866-4874

Abstract

Expression of the TI gene, also known as ST2, DER4, and Fit-1, has been shown to be associated with cell proliferation. It gives rise to two different mRNAs that encode a receptor-like protein and a soluble molecule representing the ectodomain of the receptor Term, Although T1 is a member of the IL-1R family, its biologic function is currently unknown. In this study, we have analyzed the expression of the T1 surfaceAg in murine hemopoietic organs. Mast cells (MCs) were shown to be the only identifiable cell Lineage that expressed T1 at high levels. T1 expression was Found on cultured bone marrow-derived immature MCs, Similarly, freshly isolated connective tissue-type MCs from the i.p. cavity were also shown to express high levels of T1. Interestingly, the earliest detectable committed MC precursor isolated from fetal blood (FB) at day 15.5 of gestation, but not circulating hemopoietic stem cellsin FB, also expresses high level of T1, Since FB promastocytes lack expression of the high affinity IgE receptor (Fc epsilon RI), T1 expression precedes expression of FceRI in MC ontogeny. The finding that theT1 Ag is selectively expressed at several stages during development of the MC lineage suggests that this cell surface molecule, in combination with the well-established markers c-Kit and Fc epsilon RI, should be valuable for studying the MC lineage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 08:54:46