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Titolo:
HYPERTENSION OPTIMAL TREATMENT (HOT) STUDY - A BRILLIANT CONCEPT, BUTA QUALIFIED SUCCESS
Autore:
CHALMERS J;
Indirizzi:
ROYAL N SHORE HOSP SYDNEY NSW 2065 AUSTRALIA UNIV SYDNEY SYDNEY NSW 2006 AUSTRALIA
Titolo Testata:
Journal of hypertension
fascicolo: 10, volume: 16, anno: 1998,
pagine: 1403 - 1405
SICI:
0263-6352(1998)16:10<1403:HOT(S->2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; BLOOD-PRESSURE; POPULATION; STROKE; RISK;
Keywords:
GOAL BLOOD PRESSURE; COMBINATION THERAPY; ASPIRIN AND CORONARY HEART DISEASE; CARDIOVASCULAR MORBIDITY AND MORTALITY; DIABETES; MYOCARDIAL INFARCTION; STROKE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J. Chalmers, "HYPERTENSION OPTIMAL TREATMENT (HOT) STUDY - A BRILLIANT CONCEPT, BUTA QUALIFIED SUCCESS", Journal of hypertension, 16(10), 1998, pp. 1403-1405

Abstract

Background to the study The Hypertension Optimal Treatment (HOT) study was designed to answer two questions: whether low-dose aspirin (75 mg/day) is effective in the primary prevention of myocardial infarction, without an increase in cerebral haemorrhage in hypertensive patientswhose blood pressure is well controlled, and whether there are additional benefits with a progressive reduction of diastolic blood pressurefrom 90 mmHg to below 80 mmHg, Successes In a landmark outcome, low-dose aspirin was indeed shown to be effective in the primary preventionof myocardial infarction, Moreover, the study has shed light on many important issues for blood pressure lowering in the treatment of hypertension, providing an excellent demonstration that with aggressive combination therapy, the elevated blood pressure in hypertensive subjectscan be lowered and maintained in the normotensive range in over 90% of cases. Disappointment The biggest disappointment was that the intention to treat analysis failed to demonstrate a significant difference between the three randomized target blood pressure groups for the majority of cardiovascular events. (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:12:43