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Titolo:
COMPLEMENT ACTIVATION DURING MAJOR SURGERY - THE EFFECT OF EXTRACORPOREAL CIRCUITS AND HIGH-DOSE APROTININ
Autore:
SEGAL H; SHEIKH S; KALLIS P; COTTAM S; BEARD C; POTTER D; TOWNSEND E; BIDSTRUP BP; YACOUB M; HUNT BJ;
Indirizzi:
HAREFIELD HOSP,NATL HEART & LUNG INST,DEPT CARDIOTHORAC SURG,CTR HEARING SCI HAREFIELD UB9 6JH MIDDX ENGLAND HAREFIELD HOSP,NATL HEART & LUNG INST,DEPT CARDIOTHORAC SURG,CTR HEARING SCI HAREFIELD UB9 6JH MIDDX ENGLAND UNIV LONDON KINGS COLL HOSP,DEPT ANAESTHET LONDON ENGLAND
Titolo Testata:
Journal of cardiothoracic and vascular anesthesia
fascicolo: 5, volume: 12, anno: 1998,
pagine: 542 - 547
SICI:
1053-0770(1998)12:5<542:CADMS->2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC LIVER-TRANSPLANTATION; RESPIRATORY-DISTRESS SYNDROME; CARDIOPULMONARY BYPASS; GRANULOCYTE ACTIVATION; CONTACT SYSTEM; BLOOD-LOSS; HEPARIN; DISEASE; FIBRINOLYSIS; HEMODIALYSIS;
Keywords:
COMPLEMENT; EXTRACORPOREAL CIRCULATION; APROTININ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
H. Segal et al., "COMPLEMENT ACTIVATION DURING MAJOR SURGERY - THE EFFECT OF EXTRACORPOREAL CIRCUITS AND HIGH-DOSE APROTININ", Journal of cardiothoracic and vascular anesthesia, 12(5), 1998, pp. 542-547

Abstract

Objective: To assess the in vivo contribution to complement activation of an extracorporeal circuit and the use of high-dose aprotinin during major surgery Design: Sequential samples were obtained from 8 patients undergoing thoracic surgery, 20 patients undergoing orthotopic liver transplantation (OLT) using venovenous bypass, and 19 patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Intervention:The latter two groups were part of a randomized controlled trial of high-dose aprotinin. Measurements: Total complement activation was measured with the hemolytic complement activity and the C3 activation-specific marker, C3d antigen. Main Results: Complement activation did notoccur during thoracic surgery During OLT, C3d antigen levels, expressed as mean +/- standard deviation (SD), were elevated from baseline atskin closure (8.6 +/- 2.5 v 13.0 +/- 5.2 mg/L; p = 0.0082). During cardiac surgery, C3d antigen levels increased 10 minutes after the startof CPB (pre-CPB, 8.0 +/- 1.9 v 14.2 +/- 3.1 mg/L; p = 0.0001) and remained at greater than baseline values postoperatively (8.0 +/- 1.9 v 11.8 +/- 2.3 mg/L; p = 0.002). There was no difference in complement activation in those receiving high-dose aprotinin during OLT or cardiac surgery. Complement activation during cardiac surgery using extracorporeal circulation occurred to a greater extent than during OLT and thoracic surgery. Complement activation during cardiac surgery or OLT was not attenuated by the use of high-dose aprotinin. Copyright (C) 1998 by W.B. Saunders Company.

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Documento generato il 05/04/20 alle ore 09:47:57