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Titolo:
MORPHOLOGICAL-CHANGES ASSOCIATED WITH LONG-TERM POTENTIATION
Autore:
AGNIHOTRI N; LOPEZGARCIA JC; HAWKINS RD; ARANCIO O;
Indirizzi:
COLUMBIA UNIV,COLL PHYS & SURG,CTR NEUROBIOL & BEHAV,722 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV,COLL PHYS & SURG,CTR NEUROBIOL & BEHAV NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP NEW YORK NY 10032
Titolo Testata:
Histology and histopathology
fascicolo: 4, volume: 13, anno: 1998,
pagine: 1155 - 1162
SICI:
0213-3911(1998)13:4<1155:MAWLP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEGMENTED POSTSYNAPTIC DENSITIES; CULTURED HIPPOCAMPAL-NEURONS; DEPENDENT PROTEIN-KINASE; DENDRITIC SPINE DENSITY; CENTRAL NERVOUS-SYSTEM; IMMEDIATE-EARLY GENE; RAT VISUAL-CORTEX; DENTATE GYRUS; NITRIC-OXIDE; CEREBRAL-CORTEX;
Keywords:
SYNAPTIC PLASTICITY; SYNAPSE FORMATION; STRUCTURAL CHANGES; DENDRITIC SPINES; POSTSYNAPTIC DENSITY; PRESYNAPTIC TERMINAL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
94
Recensione:
Indirizzi per estratti:
Citazione:
N. Agnihotri et al., "MORPHOLOGICAL-CHANGES ASSOCIATED WITH LONG-TERM POTENTIATION", Histology and histopathology, 13(4), 1998, pp. 1155-1162

Abstract

Long-term potentiation (LTP) is a longlasting form of synaptic plasticity induced by brief repetitive afferent stimulation that is thought to be associated with learning and memory. It is most commonly studiedin the hippocampus where it may last for several weeks, and involves the synthesis of new proteins that might play a structural role. In this review we summarize the evidence in favor of modifications of neuronal architecture during LTP. We focus our attention on changes occurring at the level of single synapses, including components of postsynaptic dendrites (dendritic spines, the postsynaptic density, and synapticcurvature), of presynaptic terminals, and the formation of new synapses. We conclude that although many morphological changes at various sites have been observed during LTP, there is no definitive proof in favor of structural changes associated with LTP. However, morphological modifications remain a valid candidate for mechanisms of learning and memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:13:56