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Titolo:
M-THPC-MEDIATED PHOTODYNAMIC THERAPY (PDT) DOES NOT INDUCE RESISTANCETO CHEMOTHERAPY, RADIOTHERAPY OR PDT ON HUMAN BREAST-CANCER CELLS IN-VITRO
Autore:
HORNUNG R; WALT H; CROMPTON NEA; KEEFE KA; JENTSCH B; PEREWUSNYK G; HALLER U; KOCHLI OR;
Indirizzi:
UNIV ZURICH HOSP,RES DIV GYNECOL,DEPT GYNECOL & OBSTET CH-8091 ZURICHSWITZERLAND UNIV ZURICH HOSP,RES DIV GYNECOL,DEPT GYNECOL & OBSTET CH-8091 ZURICHSWITZERLAND UNIV ZURICH,INST MED RADIOBIOL VILLIGEN SWITZERLAND PAUL SCHERRER INST VILLIGEN SWITZERLAND UNIV CALIF IRVINE,BECKMAN LASER INST & MED CLIN IRVINE CA 92717
Titolo Testata:
Photochemistry and photobiology
fascicolo: 4, volume: 68, anno: 1998,
pagine: 569 - 574
SICI:
0031-8655(1998)68:4<569:MPT(DN>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT MESOTHELIOMA; MITOMYCIN-C; TUMOR-MODEL; IN-VITRO; PHOTOSENSITIZERS; LINES; CARCINOMA; SENSITIVITY; COMBINATION; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R. Hornung et al., "M-THPC-MEDIATED PHOTODYNAMIC THERAPY (PDT) DOES NOT INDUCE RESISTANCETO CHEMOTHERAPY, RADIOTHERAPY OR PDT ON HUMAN BREAST-CANCER CELLS IN-VITRO", Photochemistry and photobiology, 68(4), 1998, pp. 569-574

Abstract

Photodynamic therapy (PDT) uses laser light to activate a photosensitizer that has been absorbed preferentially by cancer cells after systemic administration. A phototoxic reaction ensues resulting in cell death and tissue necrosis, Some cells, however, may survive PDT, This study was performed to determine if surviving human breast cancer cells (MCF-7) can become resistant to PDT, chemotherapy or radiotherapy. The MCF-7 cells were cultured under standard conditions prior to being exposed to the photosensitizer, 5,10,15,20-meta-tetra(hydroxyphenyl)chlorin (m-THPC), for 24 h and then irradiated with laser light (652 nm), Surviving cells were allowed to regrow by allowing a 2 week interval between each additional PDT, After the third and final treatment, colonyformation assays were used to evaluate the sensitivity of cultured cells to ionizing radiation and PDT and the ATP cell viability assay tested in vitro chemosensitivity, Flow cytometry was used to analyze the cell cycle. No alterations in the cell cycle were observed after threecycles of PDT with m-THPC, Similar responses to chemotherapy and ionizing radiation were seen in control and treatment groups. The m-THPC-sensitized PDT did not induce resistance to subsequent cycles of PDT, chemo- or radiotherapy. Photodynamic therapy with m-THPC may represent a novel adjunctive treatment of breast cancer that may be combined with surgery, chemotherapy or ionizing radiation.

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Documento generato il 04/06/20 alle ore 00:48:32