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Titolo:
QUANTITATIVE AND QUALITATIVE ALTERATIONS OF LONG-TERM CULTURE-INITIATING CELLS IN PATIENTS WITH ACUTE-LEUKEMIA IN COMPLETE REMISSION
Autore:
YAO M; BOUCHET S; HARNOIS C; GIARRATANA MC; LAPORTE JP; GORIN NC; LOPEZ M; DOUAY L;
Indirizzi:
HOP ENFANTS ARMAND TROUSSEAU,SERV HEMATOL BIOL,26 AVE DOCTEUR ARNOLD NETTER F-75012 PARIS FRANCE HOP ENFANTS ARMAND TROUSSEAU,SERV HEMATOL BIOL F-75012 PARIS FRANCE CTR CLAUDE BERNARD RECH THERAPIE CELLULAIRE PARIS FRANCE HOP ST ANTOINE,INSERM,U417 PARIS FRANCE INSERM,U76 PARIS FRANCE
Titolo Testata:
British Journal of Haematology
fascicolo: 1, volume: 103, anno: 1998,
pagine: 124 - 128
SICI:
0007-1048(1998)103:1<124:QAQAOL>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOLOGOUS BONE-MARROW; ACUTE MYELOID-LEUKEMIA; MAFOSFAMIDE ASTA-Z-7557; PERIPHERAL-BLOOD; 1ST REMISSION; TRANSPLANTATION; CHEMOTHERAPY; GROWTH; 4-HYDROPEROXYCYCLOPHOSPHAMIDE; HIERARCHY;
Keywords:
ACUTE LEUKEMIA; LONG-TERM CULTURE-INITIATING CELLS; MAFOSFAMIDE; AUTOGRAFTING; PURGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Yao et al., "QUANTITATIVE AND QUALITATIVE ALTERATIONS OF LONG-TERM CULTURE-INITIATING CELLS IN PATIENTS WITH ACUTE-LEUKEMIA IN COMPLETE REMISSION", British Journal of Haematology, 103(1), 1998, pp. 124-128

Abstract

Bone marrow (BM) samples from 24 patients with acute leukaemia (AML 17, ALL seven) in first complete remission were compared to samples from 10 normal donors with regard to their content in long-term culture-initiating cells (LTC-IC) as assessed by a limiting dilution assay and the clonogeneic capacity of these cells, in order to determine whetherremission marrow cells displayed any specific defect at the primitivestem cell level. The frequency of LTC-IC in the whole patient group was 1 in 3487 +/- 3125 mononuclear cells (MNC) as compared to 1 in 794 /- 492 MNC in normal controls (P = 0.0009), with no difference between AML and ALL. Moreover, the clonogeneic capacities were 2.66 +/- 0.7 (range 1.8-1.6) and 4.0 +/- 1.6 (range 2.2-7.9) CFC per LTC-IC in patients and controls respectively (P = 0.0015). These quantitative and qualitative defects were aggravated by treatment with mafosfamide at a dose of 50 mu g/10(7) MNC/ml, where the mean recovery of LTC-IC after in vitro purging was 42%, In nine patients autografted with purged marrow following high-dose radiochemotherapy, no correlation could be detected between the dose of LTC-IC (mean 6742 +/- 7877/kg) and the kinetics of recovery of haemopoiesis, We concluded that, in acute leukaemia patients in complete remission, the presumably normal residual stem cell pool was not only quantitatively diminished but also qualitatively altered in its capacity to give rise to clonogeneic progenitor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:41:57