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Titolo:
EFFECTS OF SHO-SAIKO-TO, SANO-SHASHIN-TO AND SCUTELLARIAE-RADIX ON INTRACELLULAR CA2-CELLS( MOBILIZATION IN C6 RAT GLIOMA)
Autore:
KYO R; NAKAHATA N; SAKAKIBARA I; KUBO M; OHIZUMI Y;
Indirizzi:
TOHOKU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT MOL BIOL,AOBA KU,ARAMAKI SENDAI MIYAGI 9808578 JAPAN TOHOKU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT MOL BIOL,AOBA KU SENDAI MIYAGI 9808578 JAPAN TSUMURA & CO,TSUMURA CENT RES LABS IBARAKI OSAKA 3001192 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 10, volume: 21, anno: 1998,
pagine: 1067 - 1071
SICI:
0918-6158(1998)21:10<1067:EOSSAS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ASTROCYTOMA-CELLS; ARACHIDONIC-ACID METABOLISM; PHOSPHOLIPASE-C; RECEPTORS; ACCUMULATION; NEUTROPHILS; MASTOPARAN; INDUCTION; CULTURE; BRAIN;
Keywords:
SHO-SAIKO-TO; SANO-SHASHIN-TO; SCUTELLARIAE RADIX; CA2+; PHOSPHOINOSITIDE HYDROLYSIS; GLIAL CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R. Kyo et al., "EFFECTS OF SHO-SAIKO-TO, SANO-SHASHIN-TO AND SCUTELLARIAE-RADIX ON INTRACELLULAR CA2-CELLS( MOBILIZATION IN C6 RAT GLIOMA)", Biological & pharmaceutical bulletin, 21(10), 1998, pp. 1067-1071

Abstract

Glial cells are able to support neurons physically and functionally, The present study was undertaken to determine the effects of Kampo medicines on glial cell function, especially Ca2+ mobilization, C6 rat glioma cells expressed H-1-histamine, muscarinic cholinergic and adrenergic alpha(1)-receptors, stimulation of which resulted in phosphoinositide hydrolysis and increase in intracellular Ca2+ concentrations ([Ca2](i)). The water extracts of Sho-saiko-to and San'o-shashin-to, Kampomedicines which contain Scutellariae Radix (Ogon, the root of Scutellaria ia baicalensis GEORGI), inhibited histamine (100 mu m)-induced increase in [Ca2+](i) in a concentration-dependent manner. The water extract of Scutellariae Radix potently decreased [Ca2+](i) in a concentration-dependent manner. Sho-saiko-to, San'o-shashin-to and ScutellariaeRadix significantly inhibited histamine-induced accumulation of total[H-3]inositol phosphates, consistent with their inhibition of the increase in [Ca2+](i). These results suggest that Sho-saiko-to, San'o-shashin-to and Scutellariae Radix inhibit Ca2+ mobilization mediated via an inhibition of phospholipase C, The inhibitory effect may be important in interpreting the pharmacological actions of above Kampo medicines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:53:17