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Titolo:
STRENGTHENING OF SYNCHRONIZED ACTIVITY BY TETANIC STIMULATION IN CORTICAL CULTURES - APPLICATION OF PLANAR ELECTRODE ARRAYS
Autore:
JIMBO Y; ROBINSON HPC; KAWANA A;
Indirizzi:
NIPPON TELEGRAPH & TEL PUBL CORP,BASIC RES LABS,3-1 MORINASATO WAKAMIYA ATSUGI KANAGAWA 243019 JAPAN UNIV CAMBRIDGE,PHYSIOL LAB CAMBRIDGE CB2 3EG ENGLAND
Titolo Testata:
IEEE transactions on biomedical engineering
fascicolo: 11, volume: 45, anno: 1998,
pagine: 1297 - 1304
SICI:
0018-9294(1998)45:11<1297:SOSABT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; EXCITATORY POSTSYNAPTIC CURRENTS; SYNAPTIC TRANSMISSION; INTRACELLULAR CALCIUM; VISUAL-CORTEX; PATCH-CLAMP; NEURONS; HIPPOCAMPUS; TRANSIENTS; MECHANISM;
Keywords:
CELL CULTURE; ELECTRODE ARRAY; NEURON; PLASTICITY; RELIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
Y. Jimbo et al., "STRENGTHENING OF SYNCHRONIZED ACTIVITY BY TETANIC STIMULATION IN CORTICAL CULTURES - APPLICATION OF PLANAR ELECTRODE ARRAYS", IEEE transactions on biomedical engineering, 45(11), 1998, pp. 1297-1304

Abstract

Rat cortical neurons were cultured on planar electrode arrays with 64embedded electrodes, Whole-cell recording from single neurons and multisite extracellular recording were carried out simultaneously in the cultured cortical networks, and the effects of focal tetanic stimulation of the culture were studied. Both the number of action potentials and the propagation velocity of stimulated bursts were increased after tetanic stimulation. These changes were associated with a marked increase in the number of late components in the synaptic current, but withlittle or no increase in the early peak synaptic current. The effectsof tetanic stimulation were consistent with a widespread increase in the reliability of monosynaptic transmission.

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Documento generato il 06/07/20 alle ore 05:55:52