Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ENHANCED MONOCYTE TISSUE FACTOR RESPONSE AFTER EXPERIMENTAL BALLOON ANGIOPLASTY IN HYPERCHOLESTEROLEMIC RABBIT - INHIBITION WITH DIETARY L-ARGININE
Autore:
CORSEAUX D; LETOURNEAU T; SIX I; EZEKOWITZ MD; MCFADDEN EP; MEURICE T; ASSEMAN P; BAUTERS C; JUDE B;
Indirizzi:
HOP CARDIOL,HEMATOL LAB,BLVD PROF J LECLERCQ F-59037 LILLE FRANCE CTR HOSP REG & UNIV LILLE,HEMATOL LAB F-59037 LILLE FRANCE CTR HOSP REG & UNIV LILLE,SERV CARDIOL & HEMODYNAM F-59037 LILLE FRANCE CTR HOSP REG & UNIV LILLE,SERV SOINS INTENS F-59037 LILLE FRANCE CTR HOSP REG & UNIV LILLE,SERV COMMUN IMAGERIE INTERVENT F-59037 LILLE FRANCE FAC MED LILLE F-59045 LILLE FRANCE YALE UNIV,SECT CARDIOVASC MED NEW HAVEN CT 00000
Titolo Testata:
Circulation
fascicolo: 17, volume: 98, anno: 1998,
pagine: 1776 - 1782
SICI:
0009-7322(1998)98:17<1776:EMTFRA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; NF-KAPPA-B; NITRIC-OXIDE; UNSTABLE ANGINA; FACTOR GENE; EXPRESSION; ACTIVATION; PLAQUE; ATHEROSCLEROSIS; ADHESIVENESS;
Keywords:
TISSUE FACTOR; MONOCYTES; NITRIC OXIDE; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D. Corseaux et al., "ENHANCED MONOCYTE TISSUE FACTOR RESPONSE AFTER EXPERIMENTAL BALLOON ANGIOPLASTY IN HYPERCHOLESTEROLEMIC RABBIT - INHIBITION WITH DIETARY L-ARGININE", Circulation, 98(17), 1998, pp. 1776-1782

Abstract

Background-There is evidence that tissue factor (TF) is a major contributor to the thrombogenicity of a ruptured atherosclerotic plaque. Nitric oxide (NO) has antiatherogenic and antithrombotic properties. We investigated whether L-arginine (L-arg), the endogenous precursor of NO, might affect the ability of monocytes to produce TF. Methods and Results-We studied TF expression in 18 rabbits with atherosclerosis induced by bilateral iliac damage and 10 weeks of a 2% cholesterol diet. Six weeks after the initiation of the diet, an angioplasty was performed. After angioplasty, the surviving rabbits (n=15) were randomized to receive L-arg (2.25%) supplementation in drinking water (L-arg group, n=8) or no treatment (untreated group, n=7). TF expression was evaluated in mononuclear cells from arterial blood in the presence and absence of endotoxin stimulation. Monocyte TF expression, as assessed with an amidolytic assay, did not differ significantly before or after the induction of atherosclerotic lesions (87+/-15 versus 70+/-12 mU of TF/1000 monocytes, P=NS). Endotoxin-stimulated TF activity increased significantly 4 weeks after angioplasty (138+/-22 versus 70+/-12 mU of TF/1000 monocytes, P=0.02). This increase was blunted by L-arg (43+/-16 mUof TF/1000 monocytes, P=0.01). Conclusions-This study demonstrates that angioplasty-induced plaque rupture is associated with a marked increase in monocyte TF response that is blunted by the oral administration of L-arg. This suggests that the documented antithrombotic properties of NO may be related in part to an inhibitory effect on monocyte TF response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 16:16:35