Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIFFERENTIAL EXPRESSION OF T-CELL ADHESION MOLECULES AND LFA-1-DEPENDENT INTERCELLULAR-ADHESION IN HGCL2-INDUCED AUTOIMMUNITY AND IMMUNE SUPPRESSION
Autore:
ROOS A; CLAESSEN N; SCHILDERTOL EJM; WEENING JJ; ATEN J;
Indirizzi:
UNIV AMSTERDAM,ACAD MED CTR,DEPT PATHOL,POB 22700 NL-1100 DE AMSTERDAM NETHERLANDS
Titolo Testata:
Scandinavian journal of immunology
fascicolo: 4, volume: 48, anno: 1998,
pagine: 389 - 396
SICI:
0300-9475(1998)48:4<389:DEOTAM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN-NORWAY RAT; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; FUNCTION-ASSOCIATED ANTIGEN-1; MERCURY-INDUCED AUTOIMMUNITY; LEWIS RATS; CROSS-LINKING; OX40 LIGAND; SYSTEMIC AUTOIMMUNITY; CHLORIDE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A. Roos et al., "DIFFERENTIAL EXPRESSION OF T-CELL ADHESION MOLECULES AND LFA-1-DEPENDENT INTERCELLULAR-ADHESION IN HGCL2-INDUCED AUTOIMMUNITY AND IMMUNE SUPPRESSION", Scandinavian journal of immunology, 48(4), 1998, pp. 389-396

Abstract

Exposure of Brown Norway (BN) rats to HgCl2 induces Th2-mediated systemic autoimmunity. In contrast, in Lewis rats, HgCl2 induces immune suppression, mediated by CD8(+) T cells. HgCl2 was previously found to enhance expression of LFA-1, ICAM-1 and CD134 (OX40) on T cells in BN rats. In the present study, T cells from Lewis rats were studied at day4 after injection of HgCl2. CD8(+) T lymphoblasts were significantly increased, which were predominantly CD45RC(hi), and which showed enhanced LFA-1 expression. Furthermore, CD4(+)CD45RC(hi) T cells showed increased numbers of ICAM-1(+) cells, whereas expression of CD134 and CD26 was relatively decreased in CD4(+) T lymphoblasts. Ex vivo experiments demonstrated that HgCl2-exposure of BN rats, but not of Lewis rats,significantly enhances PMA [phorbol 12-myristate 13-acetate]-induced lymphocyte aggregation, mediated by LFA-1 and ICAM-1. In conclusion, HgCl2-injected Lewis rats show early signs of T-lymphocyte activation, predominantly on CD8(+) cells. Strain-dependent effects of HgCl2 on cell adhesion molecules and expression of CD134 may play an important role in development of either autoimmunity or immune suppression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:25:01