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Titolo:
EMBRYONIC STRIATAL GRAFTS RESTORE NEURONAL-ACTIVITY OF THE GLOBUS-PALLIDUS IN A RODENT MODEL OF HUNTINGTONS-DISEASE
Autore:
NAKAO N; OGURA M; NAKAI K; ITAKURA T;
Indirizzi:
WAKAYAMA MED COLL,DEPT NEUROL SURG,7-27 WAKAYAMA 640 JAPAN
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 88, anno: 1999,
pagine: 469 - 477
SICI:
0306-4522(1999)88:2<469:ESGRNO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL GANGLIONIC EMINENCE; ACID-LESIONED STRIATUM; HOST DOPAMINERGIC AFFERENTS; RAT NEOSTRIATAL GRAFTS; CYTOCHROME-OXIDASE; INTRASTRIATAL INJECTIONS; FOS EXPRESSION; BASAL GANGLIA; TRANSPLANTS; CONNECTIVITY;
Keywords:
LATERAL GANGLIONIC EMINENCE; NEURAL TRANSPLANTATION; SINGLE-UNIT ACTIVITY; CYTOCHROME OXIDASE; QUINOLINIC ACID; ROTATIONAL BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
N. Nakao et al., "EMBRYONIC STRIATAL GRAFTS RESTORE NEURONAL-ACTIVITY OF THE GLOBUS-PALLIDUS IN A RODENT MODEL OF HUNTINGTONS-DISEASE", Neuroscience, 88(2), 1999, pp. 469-477

Abstract

It has been demonstrated in rats that embryonic striatal grafts placed in the excitotoxically lesioned striatum establish neuronal connections with the host globus pallidus. In order to determine whether the morphologically verified connections between the grafts and host are functional, the present study investigated the effects of embryonic striatal grafts on changes in the neuronal activity of the globus pallidusin rats with quinolinic acid-induced striatal lesions. The activity of pallidal neurons was determined by use of quantitative cytochrome oxidase histochemistry and an electrophysiological technique. Striatal lesions induced an increase in both the cytochrome oxidase activity andthe spontaneous firing rate of the globus pallidus ipsilateral to thelesions. Grafts derived from the lateral ganglionic eminence, but notthe medial ganglionic eminence, reversed the lesion-induced increase in the cytochrome oxidase activity of the globus pallidus with concomitant reduction of apomorphine-induced rotational asymmetry. The lateral ganglionic eminence grafts also attenuate the increase in the firingrate of pallidal neurons in rats with striatal lesions. The present results provide evidence that striatal lesions lead to the loss of a tonic inhibitory input to the globus pallidus with consequent increase in the activity of pallidal neurons, and that intrastriatal striatal grafts reverse the altered activity of pallidal neurons. The findings strongly suggest that embryonic striatal grafts functionally repair the damaged striatopallidal pathway. (C) 1998 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:42:18