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Titolo:
EXPRESSION OF ADHESION MOLECULES IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA - AN ANALYSIS IN LYMPHOID COMPARTMENTS - PERIPHERAL-BLOOD, BONE-MARROW AND LYMPH-NODE
Autore:
NADKARNI JJ; PERAMBAKAM SM; RATHORE VB; AMIN KM; PARIKH PM; NARESH KN; ADVANI SH;
Indirizzi:
TATA MEM HOSP,CANC RES INST,DIV IMMUNOL BOMBAY 400012 MAHARASHTRA INDIA TATA MEM HOSP,TATA MEM CTR,DEPT MED ONCOL BOMBAY 400012 MAHARASHTRA INDIA TATA MEM HOSP,TATA MEM CTR,DEPT PATHOL BOMBAY 400012 MAHARASHTRA INDIA
Titolo Testata:
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
fascicolo: 4, volume: 13, anno: 1998,
pagine: 269 - 274
SICI:
1084-9785(1998)13:4<269:EOAMIB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS LYMPHOMA; DIFFERENTIAL EXPRESSION; LEUKEMIA; RECEPTORS; LFA-1; MIGRATION; DISORDERS; ICAM-1;
Keywords:
CLL; LFA; CD44; VLA-4; HOMING; PCNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Nadkarni et al., "EXPRESSION OF ADHESION MOLECULES IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA - AN ANALYSIS IN LYMPHOID COMPARTMENTS - PERIPHERAL-BLOOD, BONE-MARROW AND LYMPH-NODE", CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 13(4), 1998, pp. 269-274

Abstract

The trafficking or homing of different lymphoid subsets to particularmicroenvironment is mediated by specific cell adhesion molecules (CAMs) expressed on lymphocytes and endothelial cells. B-cell chronic lymphocytic leukaemia (B-CLL) or Non-Hodgkin's lymphoma of small lymphocytic, B-cell type are monoclonal expansions of mature lymphocytes. The relative distribution of the tumor lymphocytes among various lymphoid compartments vary from patient to patient. Very few studies underlying this issue are available. To this effect, we have analysed the expression of LFA-1; VLA-4, ICAM-1; CD44H and CD44v6 (haematopoietic and variant form respectively) on freshly isolated lymphocytes obtained from bone marrow (BM), peripheral blood (PB) and lymph node (ZN) by flow cytometry. Overall, we find strong expression of CD44H; low to moderate expression of LFA-1, negative to low expression of VLA-4 and lack of expression of CD44v6. ICAM-1 expression was observed only in patients with prominent lymphadenopathy. Higher expression of CD44H in PB lymphoid cells relative to that of BM lymphoid cells correlated with higher PB lymphocytosis (p<0.001). Proliferating cell nuclear antigen expression in LN sections correlated inversely with VLA-4 expression on BM andPB lymphoid cells (p<0.05). There was no significant correlation between expression of CAMs and bcl-2 protein.

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Documento generato il 28/11/20 alle ore 18:26:44