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Titolo:
SIGNALING PATHWAY BY WHICH TGF-BETA-1 INCREASES EXPRESSION OF LATENT TGF-BETA BINDING PROTEIN-2 AT THE TRANSCRIPTIONAL LEVEL
Autore:
AHMED W; KUCICH U; ABRAMS W; BASHIR M; ROSENBLOOM J; SEGADE F; MECHAM R; ROSENBLOOM J;
Indirizzi:
UNIV PENN,SCH DENT MED,DEPT ANAT & HISTOL,4001 SPRUCE ST PHILADELPHIAPA 19104 UNIV PENN,SCH DENT MED,DEPT ANAT & HISTOL PHILADELPHIA PA 19104 WASHINGTON UNIV,DEPT CELL BIOL ST LOUIS MO 63110
Titolo Testata:
Connective tissue research (Print)
fascicolo: 3-4, volume: 37, anno: 1998,
pagine: 263 - 276
SICI:
0300-8207(1998)37:3-4<263:SPBWTI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; MOLECULAR-WEIGHT COMPLEX; XENOPUS-LAEVIS OOCYTES; SMOOTH-MUSCLE CELLS; KINASE-C; TRANSFORMING GROWTH-FACTOR-BETA-1; PHOSPHOLIPASE-C; EPITHELIAL-CELLS; MARFAN-SYNDROME; EXTRACELLULAR-MATRIX;
Keywords:
TRANSFORMING GROWTH FACTOR-BETA; LATENT TRANSFORMING GROWTH FACTOR-BETA BINDING PROTEINS; GENE TRANSCRIPTION; PROTEIN KINASE C; ELASTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
W. Ahmed et al., "SIGNALING PATHWAY BY WHICH TGF-BETA-1 INCREASES EXPRESSION OF LATENT TGF-BETA BINDING PROTEIN-2 AT THE TRANSCRIPTIONAL LEVEL", Connective tissue research (Print), 37(3-4), 1998, pp. 263-276

Abstract

The cytokine transforming growth factor-beta has multiple effects on a wide variety of cell types. These effects include modulation of growth and regulation of gene transcription. In the present work, we demonstrate that TGP-beta 1 increases transcription of the latent transforming growth factor-beta binding protein-2(LTBP-2) gene in cultured human fetal lung fibroblasts leading to a significant increase in LTBP-2 mRNA steady state level. The stability of LTBP-2 mRNA was not appreciably altered. A corresponding increase in production of LTBP-2 protein accompanied the increase in mRNA, Through the use of specific inhibitors, we demonstrate that a member of the Ras super family and a protein kinase C, probably of the atypical (non-diacylglycerol, non-Ca++ dependent) class are likely to be components in the signaling pathway. However, phospholipases, G proteins and extracellular-signal regulated kinases do not appear to be involved. These results combined with previous findings on elastin regulation by TGF-beta 1 (Kucich et al. (1997), Am. J, Respir. Cell Mol. Biol., 17: 10-16) demonstrate that TGF-beta 1can coordinately increase the steady state levels of mRNAs encoding components of the elastic fiber, but through diverse mechanisms. In contrast to LTBP-2, increased elastin expression is achieved by message stabilization. Furthermore, the TGP-beta 1 signaling pathways differ and while the pathway leading to increased LTBP-2 transcription shares components with those modulating transcription of other genes, it is unlikely to be precisely congruent with any other previously described one.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:08:01