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Titolo:
IMPAIRED GLUCOSE-TOLERANCE, TYPE-2 DIABETES, AND CAROTID WALL THICKNESS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY
Autore:
WAGENKNECHT LE; DAGOSTINO RB; HAFFNER SM; SAVAGE PJ; REWERS M;
Indirizzi:
WAKE FOREST UNIV,SCH MED,DEPT PUBL HLTH SCI,MED CTR BLVD WINSTON SALEM NC 27157 UNIV TEXAS,HLTH SCI CTR,DEPT MED SAN ANTONIO TX 78284 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV COLORADO,HLTH SCI CTR,DEPT PREVENT MED BIOMETR DENVER CO 80262
Titolo Testata:
Diabetes care
fascicolo: 11, volume: 21, anno: 1998,
pagine: 1812 - 1818
SICI:
0149-5992(1998)21:11<1812:IGTDAC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR RISK-FACTORS; B-MODE ULTRASOUND; ARTERIAL-WALL; MELLITUS; SENSITIVITY; HYPERGLYCEMIA; PROGRESSION; GLYCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Wagenknecht et al., "IMPAIRED GLUCOSE-TOLERANCE, TYPE-2 DIABETES, AND CAROTID WALL THICKNESS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY", Diabetes care, 21(11), 1998, pp. 1812-1818

Abstract

OBJECTIVE - To assess whether people with impaired glucose tolerance (IGT) exhibit an increased risk of atherosclerosis as measured by the thickness of the carotid artery. RESEARCH DESIGN AND METHODS - We examined the relationship between glucose tolerance status and subclinicalatherosclerosis in the Insulin Resistance Atherosclerosis Study (IRAS). The IRAS is an epidemiological study of 1,625 Hispanic, African-American, and white men and women, with approximately equal numbers of subjects with normal glucose tolerance (NGT), IGT, and type 2 diabetes as assessed by an oral glucose tolerance test. Half of those with diabetes were previously unaware of their condition and were defined as having new diabetes. Persons using insulin were excluded, The intima-media thickness (IMT) of the common carotid artery (CCA) and internal carotid artery (ICA) was measured as an index of subclinical atherosclerosis using B-mode ultrasonography, RESULTS - Adjusted for demographics and smoking, CCA-IMT increased most notably at the level of establisheddiabetes (802, 822, 831, and 896 mu m for NGT, IGT, new diabetes, andestablished diabetes, respectively). Adjustment for coronary heart disease (CHD) risk factors, which tended to worsen across glucose tolerance category, further minimized the slightly graded relationship. The relationship with the ICA-IMT was steeper and again suggested that theincreased wall thickness is associated with diabetes, not with IGT, The relationship between glucose tolerance category and IMT was similarin men and women, CONCLUSIONS - We observed considerably greater IMT among persons with established diabetes but no significant increase inpersons with IGT. These data suggest that the increased risk of CHD observed in persons with diabetes may largely develop after the onset of overt diabetes.

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Documento generato il 01/12/20 alle ore 11:03:30