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Titolo:
EFFECT OF THE VIABLE-YELLOW (A(VY)) AGOUTI ALLELE ON SKIN TUMORIGENESIS AND HUMORAL HYPERCALCEMIA IN V-HA-RAS TRANSGENIC TG.AC MICE
Autore:
HANSEN LA; MALARKEY DE; WILKINSON JE; ROSENBERG M; WOYCHIK RE; TENNANT RW;
Indirizzi:
NCI,CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB,BLDG 37,ROOM 3B17,37 CONVENT DR,MSC 4255 BETHESDA MD 20892 NIEHS,LAB ENVIRONM CARCINOGENESIS & MUTAGENESIS RES TRIANGLE PK NC 27709 NIEHS,LAB EXPT PATHOL RES TRIANGLE PK NC 27709 UNIV TENNESSEE KNOXVILLE TN 00000 GLAXO WELLCOME INC RES TRIANGLE PK NC 27709 OAK RIDGE NATL LAB OAK RIDGE TN 00000
Titolo Testata:
Carcinogenesis (New York. Print)
fascicolo: 10, volume: 19, anno: 1998,
pagine: 1837 - 1845
SICI:
0143-3334(1998)19:10<1837:EOTV(A>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE SKIN; GENE; PROLIFERATION; CARCINOMAS; MUTATION; GROWTH; TUMORS; COLOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Hansen et al., "EFFECT OF THE VIABLE-YELLOW (A(VY)) AGOUTI ALLELE ON SKIN TUMORIGENESIS AND HUMORAL HYPERCALCEMIA IN V-HA-RAS TRANSGENIC TG.AC MICE", Carcinogenesis (New York. Print), 19(10), 1998, pp. 1837-1845

Abstract

We previously reported that papillomas can arise from the follicular epithelium of v-Ha-ras transgenic TG.AC mice. Since the viable-yellow mutation (A(vy)) Of the mouse agouti gene which regulates coat color pigmentation by acting within the micro-environment of the hair follicle has been shown to function as a tumor promoter in the liver, we hypothesized that it may also play a role in TG.AC skin tumorigenesis. Endogenous agouti protein product was detected in the outer root sheath of anagen hair follicles following plucking of the hair shaft, but not in the interfollicular epithelium, in TG.AC mice on an FVB/N genetic background. It was also detected in papillomas from these mice producedby 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment or plucking. Expression of the A(vy) allele in the v-Ha-ms transgenic TG.AC mouse line results in an similar to 2-fold increase in papilloma development compared with controls which did not carry the A(vy) allele following twice-weekly treatment with 1.25, 2.5 or 5.0 mu g TPA. In addition, TPA-treated, papilloma-bearing F-1 mice which carried the A(vy) allele, but not F-1 mice which did not carry the A(vy) allele, exhibited a syndrome of humoral hypercalcemia mediated by parathyroid hormone-relatedprotein (PTHrP) that led to weight loss, hypercalcemia and hypophosphatemia, Thus, we conclude that the A(vy) allele can influence the development of skin tumors and PTHrP-mediated humoral hypercalcemia in v-Ha-ras transgenic TG.AC mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:08:10