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Titolo:
HEPATITIS-A VACCINE IN HEALTHY-ADULTS - A COMPARISON OF IMMUNOGENICITY AND REACTOGENICITY BETWEEN 2-DOSE AND 3-DOSE REGIMENS
Autore:
LU MY; CHANG MH; TSAI KS; CHEN DS;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT PEDIAT,NO 7 CHUNG SHAN S RD TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,DEPT PEDIAT TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT LAB MED TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,HEPATITIS RES CTR TAIPEI TAIWAN
Titolo Testata:
Vaccine
fascicolo: 1, volume: 17, anno: 1999,
pagine: 26 - 30
SICI:
0264-410X(1999)17:1<26:HVIH-A>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
A VIRUS-INFECTION; IMMUNE-RESPONSE; SAFETY; VOLUNTEERS; CHILDREN; SCHEDULE; DISEASE; TAIWAN;
Keywords:
HEPATITIS A VACCINE; IMMUNIZATION; ADULTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.Y. Lu et al., "HEPATITIS-A VACCINE IN HEALTHY-ADULTS - A COMPARISON OF IMMUNOGENICITY AND REACTOGENICITY BETWEEN 2-DOSE AND 3-DOSE REGIMENS", Vaccine, 17(1), 1999, pp. 26-30

Abstract

Inactivated hepatitis A virus (HAV) vaccine was administered to 55 healthy seronegative adult volunteers to evaluate the immunogenicity andadverse reactions of two doses of HAV vaccination (25 units) in comparison with a three-dose regimen. The volunteers were randomly assignedto receive one of the two regimens: 26 were vaccinated with two dosesat 0 and 24 weeks (Group 1), and 29 were vaccinated with three doses at 0, 2, and 24 weeks (Group 2). The vaccine was well tolerated and there was no serious adverse reaction. In both groups, the seroconversion rate was 100% at week 28. At week 52, all remained positive for anti-HAV regardless of a two- or three-dose regimen. No statistically significant difference in seroconversion rates and geometric mean titers could be demonstrated between the two groups. Thus, the two-dose regimen may be favorable to save cost and time for active immunization against hepatitis A. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:08:05