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Titolo:
THE EFFECTS OF IN-VITRO INCUBATION WITH ACETYLSALICYLIC-ACID ON THROMBOCYTE AGGREGATION IN WHOLE-BLOOD FROM NORMAL OSTRICHES
Autore:
THOMAS JS; BLUEMCLENDON A;
Indirizzi:
TEXAS A&M UNIV,COLL VET MED,DEPT VET PATHOBIOL COLLEGE STN TX 77843 TEXAS A&M UNIV,COLL VET MED,DEPT VET PHYSIOL & PHARMACOL COLLEGE STN TX 77843
Titolo Testata:
Comparative haematology international
fascicolo: 3, volume: 8, anno: 1998,
pagine: 137 - 141
SICI:
0938-7714(1998)8:3<137:TEOIIW>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING FACTOR; CHICKEN THROMBOCYTES; MECHANISMS; INTEGRIN; ASPIRIN;
Keywords:
AGGREGATION; ASPIRIN; COLLAGEN; OSTRICH; PLATELET ACTIVATING FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Thomas e A. Bluemclendon, "THE EFFECTS OF IN-VITRO INCUBATION WITH ACETYLSALICYLIC-ACID ON THROMBOCYTE AGGREGATION IN WHOLE-BLOOD FROM NORMAL OSTRICHES", Comparative haematology international, 8(3), 1998, pp. 137-141

Abstract

Avian thrombocytes are circulating nucleated blood cells which play an active role in both haemostasis and phagocytosis. To better define their role in haemostasis, thrombocyte aggregation was measured in whole blood from healthy adult ostriches using an electrical impedance aggregometer. Thrombocytes were stimulated with collagen (5 mu g/ml or 1 mu g/ml), platelet-activating factor (PAF (0.1 mu M, 0.01 mu M, or 0.001 mu M), or ADP (25 mu M). Irreversible aggregation occurred consistently in response to collagen or PAF but not to ADP. Aggregation in response to high concentrations of PAF or collagen was not affected by invitro incubation with 500 mu M aspirin. Aggregation in response to low concentrations of PAF or collagen was partially inhibited by in vitro incubation with 500 mu M aspirin, suggesting the presence of a prostaglandin-dependent mechanism for regulation of thrombocyte activation similar to that in mammalian platelets.

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Documento generato il 29/03/20 alle ore 01:36:44