Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHANGES OF MYOCARDIAL HIGH-ENERGY PHOSPHATES WITH THE CARDIAC CYCLE DURING ACUTE OR CHRONIC MYOCARDIAL STRESS
Autore:
ILLING B; HORN M; URBAN B; STROMER H; SCHNACKERZ K; DEGROOT M; HAASE A; HU K; ERTL G; NEUBAUER S;
Indirizzi:
UNIV WURZBURG,MED KLIN,JOSEF SCHNEIDER STR 2 D-97080 WURZBURG GERMANY UNIV WURZBURG,MED KLIN D-97080 WURZBURG GERMANY THEODOR BOVERI INST BIOWISSENSCH WURZBURG GERMANY UNIV WURZBURG,INST PHYS D-8700 WURZBURG GERMANY
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 5, volume: 40, anno: 1998,
pagine: 727 - 732
SICI:
0740-3194(1998)40:5<727:COMHPW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; MECHANICAL FUNCTION; RAT HEARTS; INFARCTION; METABOLISM; INVIVO; ENDOTHELIN-1;
Keywords:
ATP; CARDIAC CYCLE; HYPOXIA; CHRONIC HEART FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
B. Illing et al., "CHANGES OF MYOCARDIAL HIGH-ENERGY PHOSPHATES WITH THE CARDIAC CYCLE DURING ACUTE OR CHRONIC MYOCARDIAL STRESS", Magnetic resonance in medicine, 40(5), 1998, pp. 727-732

Abstract

Whether changes of cardiac high-energy phosphate concentrations occurover the cardiac cycle remains controversial, The hypothesis was thatsuch cyclical changes are accentuated during acute or chronic myocardial stress, Isolated rat hearts were perfused under four conditions: (1) control, (2) inotropic stimulation by doubling of perfusate [Ca2+],(3) acute hypoxia (buffer PO2 similar to 150 torr), and (4) failing, chronically infarcted hearts, P-31-MR spectra were obtained at seven time points of the cardiac cycle, Under control conditions, cyclical changes (''cycling'') of ATP (11 +/- 3%, *P < 0.05) and phosphocreatine(9 +/- 2%) were detected, inorganic phosphate cycling did not reach statistical significance, At high [Ca2+] perfusion, cycling of phosphocreatine (9 +/- 5%) was not accentuated, cycling of ATP and inorganicphosphate did not reach significance, During acute hypoxia, cycling of ATP (10 +/- 4%) and inorganic phosphate (11 +/- 4%*) occurred, but cyclical changes of phosphocreatine were not significant. In chronically infarcted hearts, the extent of cyclical changes of ATP, phosphocreatine, and inorganic phosphate was not accentuated, Thus, in perfused rat heart, small oscillations of high-energy phosphates during the cardiac cycle are detectable, but such changes are not accentuated duringacute or chronic stress. The concentrations of high-energy phosphatesover the cardiac cycle are tightly regulated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:49:05