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Titolo:
DIFFERENCES IN CEREBRAL ACTIVATION DURING SMOOTH-PURSUIT AND SACCADICEYE-MOVEMENTS USING POSITRON-EMISSION-TOMOGRAPHY
Autore:
ODRISCOLL GA; STRAKOWSKI SM; ALPERT NM; MATTHYSSE SW; RAUCH SL; LEVY DL; HOLZMAN PS;
Indirizzi:
MCGILL UNIV,DEPT PSYCHOL,STEWART BIOL SCI BLDG,1205 DR PENFIELD AVE MONTREAL PQ H3A 1B1 CANADA UNIV CINCINNATI,COLL MED,PSYCHOT DISORDERS PROGRAM CINCINNATI OH 00000 MASSACHUSETTS GEN HOSP,DEPT NUCL MED BOSTON MA 02114 MCLEAN HOSP,PSYCHOL RES LAB BELMONT MA 02178 MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT BOSTON MA 02114 HARVARD UNIV,DEPT PSYCHOL CAMBRIDGE MA 02138
Titolo Testata:
Biological psychiatry
fascicolo: 8, volume: 44, anno: 1998,
pagine: 685 - 689
SICI:
0006-3223(1998)44:8<685:DICADS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; TRACKING DYSFUNCTIONS; PET; DEFICITS; LESIONS; CORTEX; MT;
Keywords:
SMOOTH PURSUIT; SACCADES; SCHIZOPHRENIA; POSITRON-EMISSION TOMOGRAPHY; FRONTAL LOBE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Odriscoll et al., "DIFFERENCES IN CEREBRAL ACTIVATION DURING SMOOTH-PURSUIT AND SACCADICEYE-MOVEMENTS USING POSITRON-EMISSION-TOMOGRAPHY", Biological psychiatry, 44(8), 1998, pp. 685-689

Abstract

Background: Abnormalities of smooth pursuit eye movements occur commonly in schizophrenia, but the pathophysiological significance of theseabnormalities is unknown. To address this, the authors conducted a pilot study in which we examined differences in regional cerebral activation using positron-emission tomography (PET) in normal volunteers as they performed two types of eye movements. Methods: Cerebral activation in 10 normal volunteers was studied using (CO2)-O-15 PET while subjects tracked a visual target using smooth pursuit and saccadic eye movements. A left-hand movement comparison task provided a physiologic landmark for verification of the location of the frontal eye fields (FEFs). Results: Subjects exhibited FEF activation during both smooth pursuit and saccadic eye movements, which was greater in the latter. Duringsmooth pursuit, subjects also exhibited increased cerebral activationin the left temporal-occipital border and left superior frontal cortex and decreased activation in medial superior parietal and insular regions relative to saccades. Other cortical visual and eye-movement brain regions also demonstrated differences in activation between the two visual tasks. Conclusions: Significant fEF activation appears to underlie both smooth pursuit and saccadic eye movements but may be more critical in the former. Dysfunction of the frontal lobe, and possibly of other areas in the pursuit pathway such as the temporo-occipital motion area, may contribute to observed eye-movement abnormalities in patients with schizophrenia. Biol Psychiatry 1998;44: 685-689 (C) 1998 Society of Biological Psychiatry.

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Documento generato il 12/07/20 alle ore 09:42:27