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Titolo:
ENVIRONMENTAL TOXICANTS AND FEMALE REPRODUCTION
Autore:
SHARARA FI; SEIFER DB; FLAWS JA;
Indirizzi:
UNIV MARYLAND,SCH MED,DEPT OBSTET GYNECOL & REPROD SCI,DIV REPROD ENDOCRINOL & INFERTIL BALTIMORE MD 21201 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT OBSTET GYNECOL & REPROD SCI NEW BRUNSWICK NJ 00000 UNIV MARYLAND,SCH MED,DEPT EPIDEMIOL & PREVENT MED BALTIMORE MD 21201
Titolo Testata:
Fertility and sterility
fascicolo: 4, volume: 70, anno: 1998,
pagine: 613 - 622
SICI:
0015-0282(1998)70:4<613:ETAFR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIEPOXIDE-INDUCED OVOTOXICITY; CIGARETTE-SMOKING; POLYCHLORINATED-BIPHENYLS; SPONTANEOUS-ABORTION; WOMEN WORKING; IN-UTERO; DEVELOPMENTAL TOXICITY; OCCUPATIONAL EXPOSURES; PRENATAL EXPOSURE; ORGANIC-SOLVENTS;
Keywords:
ENVIRONMENTAL TOXICANTS; ENDOCRINE DISRUPTORS; IMMUNE TOXINS; REPRODUCTION; DIOXINS; CIGARETTE SMOKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
100
Recensione:
Indirizzi per estratti:
Citazione:
F.I. Sharara et al., "ENVIRONMENTAL TOXICANTS AND FEMALE REPRODUCTION", Fertility and sterility, 70(4), 1998, pp. 613-622

Abstract

Objective: To review current knowledge on the potential effects of environmental toxicants on female reproduction in laboratory animals, wildlife, and humans. Design: Published literature about the effects of endocrine disrupters, heavy metals, solvents, pesticides, plastics, industrial chemicals, and cigarette smoke on female reproduction. Result(s): Published data indicate that chemical exposures may cause alterations in reproductive behavior and contribute to subfecundity, infertility, pregnancy loss, growth retardation, intrauterine fetal demise, birth defect, and ovarian failure in laboratory animals and wildlife. Data on the association of chemical exposures and adverse reproductive outcomes in humans are equivocal and often controversial. Some studies indicate that chemical exposures are associated with infertility, spontaneous abortion, or reproductive cancer in women. In contrast, other studies indicate that there is no association between chemical exposures and adverse reproductive outcomes. The reasons for ambiguous findings in human studies are unknown but likely include the fact that many studies are limited by multiple confounders, inadequate methodology, inappropriate endpoints, and small sample size. The mechanism by which chemicals alter reproductive function in all species is complex and may involve hormonal and/or immune disruption, DNA adduct formation, altered cellular proliferation, or inappropriate cellular death. Conclusion(s): Studies are needed to clarify which toxicants affect human reproduction and by which mechanisms of action. Furthermore, methods should be developed to minimize exposure to known reproductive toxicants such as dioxins and cigarette smoke. (Fertil Steril(R) 1998;70:613-22. (C) 1998 by American Society for Reproductive Medicine.)

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:19:57