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Titolo:
PSYCHOTROPIC DRUG-INDUCED SEXUAL FUNCTION DISORDERS - DIAGNOSIS, INCIDENCE AND MANAGEMENT
Autore:
CLAYTON DO; SHEN WW;
Indirizzi:
ST LOUIS UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63104 ST LOUIS UNIV,SCH MED,DEPT PSYCHIAT ST LOUIS MO 63104
Titolo Testata:
Drug safety
fascicolo: 4, volume: 19, anno: 1998,
pagine: 299 - 312
SICI:
0114-5916(1998)19:4<299:PDSFD->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUVOXAMINE-INDUCED ANORGASMIA; SEROTONIN REUPTAKE INHIBITORS; PREMATURE EJACULATION; FEMALE ORGASM; DOUBLE-BLIND; ANTIDEPRESSANT MEDICATION; FLUOXETINE TREATMENT; PAROXETINE TREATMENT; BULIMIA-NERVOSA; DYSFUNCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
109
Recensione:
Indirizzi per estratti:
Citazione:
D.O. Clayton e W.W. Shen, "PSYCHOTROPIC DRUG-INDUCED SEXUAL FUNCTION DISORDERS - DIAGNOSIS, INCIDENCE AND MANAGEMENT", Drug safety, 19(4), 1998, pp. 299-312

Abstract

The human sexual response can be divided into 3 phases: desire (libido), excitement (arousal) and orgasm. The fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) classifies sexual disorders into 4 categories: (i) primary; (ii) general medical condition-related; (iii) substance-induced; and (iv) 'not otherwise specified' sexual dysfunctions. Each of the 4 DSM-nr categories has disorders in all 3 sexual phases. Substance-induced sexual dysfunctions are caused by the use of either substances of abuse [alcohol (ethanol), amphetamines, cocaine, opioids or sedatives/hypnotics/anxiolytics], or prescription medications which include psychotropic drugs. Patients withpsychiatric difficulties tend to experience more frequent sexual function disturbances. The literature provides more than anecdotal evidence that psychotropic drugs can induce sexual function disorders in the epidemiologically vulnerable population of psychiatric patients. Sexual dysfunctions caused by psychotropic drugs can be divided into 2 groups: sexual inhibition (inhibited desire, inhibited arousal and inhibited orgasm) and increased sexual function disorders (increased sexual desire, priapism and premature ejaculation). The diagnosis of psychotropic drug-induced sexual function disorders is easy if the psychiatristis sensitive to the existence of these adverse effects. This mostly involves careful history taking, although several questionnaires have been developed for reliable and valid quantification of sexual functioning. Diagnosis is usually established if the sexual function disordersdevelop when the patient is receiving a psychotropic drug and then disappear when the offending drug is discontinued. The management of psychotropic-drug induced sexual inhibition can be divided into 6 steps: inform the patient about the possibility of sexual inhibition occurring before prescribing a psychotropic agent; wait for remission or tolerance of sexual inhibition; reduce the dosage of the psychotropic drug;switch the medication to one less likely to cause sexual inhibition; if possible, adjust the concomitant nonpsychotropic drugs; and add various pharmacological agents to the existing psychotropic drug to treatthe sexual inhibition. Physicians should take sexual histories as a routine practice when prescribing psychotropic drugs. Through careful management and patience on the part of both the patient and the physician, psychotropic drug-induced sexual function disorders can be improved so that the patient's compliance with medication and quality of lifecan be optimised.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:44:13