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Titolo:
DIFFERENCES IN BLOOD-TUMOR-BARRIER LEAKAGE OF HUMAN INTRACRANIAL TUMORS - QUANTITATIVE MONITORING OF VASOGENIC EDEMA AND ITS RESPONSE TO GLUCOCORTICOID TREATMENT
Autore:
ANDERSEN C; JENSEN FT;
Indirizzi:
AALBORG HOSP,DEPT NEUROSURG DK-9000 AALBORG DENMARK AARHUS UNIV HOSP,DEPT NEUROSURG AARHUS DENMARK AARHUS UNIV HOSP,DEPT NEURORADIOL AARHUS DENMARK AARHUS UNIV HOSP,SKEJBY HOSP,MR CTR DK-8000 AARHUS DENMARK
Titolo Testata:
Acta neurochirurgica
fascicolo: 9, volume: 140, anno: 1998,
pagine: 919 - 924
SICI:
0001-6268(1998)140:9<919:DIBLOH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE TREATMENT; OXYGEN UTILIZATION; EDEMA; BRAIN; PERMEABILITY; MENINGIOMAS; GLIOMAS; DTPA; FLOW;
Keywords:
CAPILLARY PERMEABILITY; BRAIN TUMORS; MENINGIOMAS; GLUCOCORTICOIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
C. Andersen e F.T. Jensen, "DIFFERENCES IN BLOOD-TUMOR-BARRIER LEAKAGE OF HUMAN INTRACRANIAL TUMORS - QUANTITATIVE MONITORING OF VASOGENIC EDEMA AND ITS RESPONSE TO GLUCOCORTICOID TREATMENT", Acta neurochirurgica, 140(9), 1998, pp. 919-924

Abstract

Purpose. To study differences in tumour capillary permeability as expressed by the unidirectional transport rate constant K-i, extracellular distribution volume V-d and relaxation time T1 in human intracranialtumours using a recently described MRI method, and apply the model tostudy differences in these parameters after glucocorticoid (GC) treatment. Patients and Methods. Seventeen brain tumour patients were studied. There were seven glioblastoma (GLI), four metastasis (MET), and six meningioma (MM) patients. Nine patients were studied before and after an average of 6 days of GC treatment. A 1.5 Tesla MR imaging scannerwas used, and a two compartment diffusion model for Gd-DTPA was applied. Results. There was a significant difference between pre-treatment K-i in GLI's and MM's, MM's having the highest permeability. There were no significant differences between pre-treatment V-d or T1 among thedifferent tumour types. After GC treatment K-i decreased 15% on average (52% in GLI's and MET's, but only 4% in MM's). V-d decreased 14% onaverage in all rumours, but 47% in GLI's and MET's (p < 0.04), but increased 2% during treatment of MM's. T1 decreased 9% in all rumours (p< 0.04), but 11% in GLI's and MET's (p < 0.003), and only 6% in MM's. Conclusions. It is possible to estimate K-i, V-d and T1 simultaneously in brain tumour patients in a clinical MRI system. K-i was significantly higher in MM's compared to GLI's and MET's, suggesting that MM's differ in some physiological parameter at the blood-tumour interface. MM's did not respond to GC treatment, neither in K-i, V-d nor in T1, whereas GLI's and MET's primarily decreased their extracellular distribution volume: suggesting that this may be an important effect in GC's mode of action in these tumour types.

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Documento generato il 09/04/20 alle ore 00:31:41