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Titolo:
SELECTIVE KILLING OF GLIOMA CELL-LINES USING AN ASTROCYTE-SPECIFIC EXPRESSION OF THE HERPES-SIMPLEX VIRUS THYMIDINE KINASE GENE
Autore:
VANDIER D; RIXE O; BRENNER M; GOUYETTE A; BESNARD F;
Indirizzi:
SYNTHELABO RECH,10 RUE CARRIERES F-92500 RUEIL MALMAISON FRANCE SYNTHELABO RECH F-92500 RUEIL MALMAISON FRANCE INST GUSTAVE ROUSSY,DEPT MED F-94805 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT PHARMACOTOXICOL & PHARMACOGENET,CNRS,UMR 1772 F-94805 VILLEJUIF FRANCE NINCDS BETHESDA MD 20892
Titolo Testata:
Cancer research
fascicolo: 20, volume: 58, anno: 1998,
pagine: 4577 - 4580
SICI:
0008-5472(1998)58:20<4577:SKOGCU>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; TRANSGENIC MICE; BRAIN-TUMORS; PROMOTER; GANCICLOVIR; THERAPY; GFAP; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
D. Vandier et al., "SELECTIVE KILLING OF GLIOMA CELL-LINES USING AN ASTROCYTE-SPECIFIC EXPRESSION OF THE HERPES-SIMPLEX VIRUS THYMIDINE KINASE GENE", Cancer research, 58(20), 1998, pp. 4577-4580

Abstract

Gene therapy using the herpes simplex virus thymidine kinase gene (HSV-TK) is a promising new approach for the treatment of gliomas, a tumor type with a poor prognosis. To limit the toxic effects of this procedure, it is desirable to restrict expression of the HSV-TK gene to thetarget cells. This can be accomplished by use of the promoter of the glial fibrillary acidic protein gene, an intermediate filament proteinexpressed primarily in astrocytes. A plasmid containing the HSV-TK gene, driven by the human glial fibrillary acidic protein promoter gfa2,was lipofected into glioma cell lines and into an ovarian cancer fellline. Treatment with ganciclovir showed efficient killing of glioma cells, with no effect on the ovarian cells. Thus, the gfa2 promoter is a promising candidate for directing expression of toxic genes to gliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 03:59:58