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Titolo:
EFFECTS OF EARLY POSTNATAL DEXAMETHASONE THERAPY ON CALCIUM HOMEOSTASIS AND BONE-GROWTH IN PRETERM INFANTS WITH RESPIRATORY-DISTRESS SYNDROME
Autore:
LIN YJ; YEH TF; LIN HC; WU JM; LIN CH; YU CY;
Indirizzi:
NATL CHENG KUNG UNIV HOSP,DEPT PAEDIAT,138 SHENG LI RD TAINAN TAIWAN NATL CHENG KUNG UNIV HOSP,DEPT PEDIAT TAINAN TAIWAN NATL CHENG KUNG UNIV HOSP,DEPT RADIOL TAINAN TAIWAN CHINA MED COLL HOSP,DEPT PEDIAT TAICHUNG TAIWAN
Titolo Testata:
Acta paediatrica
fascicolo: 10, volume: 87, anno: 1998,
pagine: 1061 - 1065
SICI:
0803-5253(1998)87:10<1061:EOEPDT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LUNG-DISEASE; BRONCHOPULMONARY DYSPLASIA; CONTROLLED TRIAL; PREMATURE-INFANTS; GLUCOCORTICOIDS; VENTILATION; CHILDREN;
Keywords:
CALCIUM HOMEOSTASIS; DEXAMETHASONE; PARATHYROID HORMONE; PRETERM INFANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Lin et al., "EFFECTS OF EARLY POSTNATAL DEXAMETHASONE THERAPY ON CALCIUM HOMEOSTASIS AND BONE-GROWTH IN PRETERM INFANTS WITH RESPIRATORY-DISTRESS SYNDROME", Acta paediatrica, 87(10), 1998, pp. 1061-1065

Abstract

The effects of dexamethasone therapy on calcium homeostasis and bone growth were evaluated in 49 infants (24 placebo and 25 dexamethasone) who participated in a double-blind trial of early dexamethasone therapy for the prevention of chronic lung disease. Dexamethasone (0.25 mg kg(-1) b.i.d. on d 1-7; 0.12 mg kg(-1) b,i,d. on d 8-14; 0.05 mg kg(-1)b.i.d. on d 15-21; 0.02 mg kg(-1) b.i.d. on d 22-28) or saline placebo was given i.v. Serum calcium (Ca), phosphorus (P) and parathyroid hormone (PTH), and the corresponding urinary excretion of calcium (FECa)and phosphorus (FEp) were measured on d 2, 3, 7, 10, 14, 21 and 28 after starting the study. Radiographic evaluations of bone growth were also evaluated. Infants in the dexamethasone group had significantly higher PTH on d 2 (p < 0.01), 7 and 14 (p < 0.05) than infants in the placebo group. The dexamethasone-treated infants also had significantly higher FEp on d 2, 7 and 14 (p < 0.05) and lower FECa on d 7 and 14 (p< 0.05) than control infants. There was no significant difference between the groups in bone growth during the study. It was concluded thatearly dexamethasone therapy causes a transient elevation in PTH without apparent change in bone growth. The long-term effect remains to be evaluated further.

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Documento generato il 05/07/20 alle ore 10:30:45