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Titolo:
HPRT-MUTANT FREQUENCY AND LYMPHOCYTE CHARACTERISTICS OF WORKERS EXPOSED TO IONIZING-RADIATION ON A SPORADIC BASIS - A COMPARISON OF 2 EXPOSURE INDICATORS, JOB TITLE AND DOSE
Autore:
SEIFERT AM; DEMERS C; DUBEAU H; MESSING K;
Indirizzi:
UNIV QUEBEC,CINBIOSE,CP 8888,SUCCURSALE A MONTREAL R3C 3P8 PQ CANADA UNIV QUEBEC,CINBIOSE,CP 8888,SUCCURSALE A MONTREAL R3C 3P8 PQ CANADA
Titolo Testata:
MUTATION RESEARCH
fascicolo: 1, volume: 319, anno: 1993,
pagine: 61 - 70
SICI:
0027-5107(1993)319:1<61:HFALCO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; NUCLEAR-MEDICINE PATIENTS; BREAST-CANCER PATIENTS; MUTATION FREQUENCY; 6-THIOGUANINE RESISTANCE; CIRCULATING LYMPHOCYTES; INVIVO; INDUCTION; CELLS; GENE;
Keywords:
HPRT-MUTANT FREQUENCY; LYMPHOCYTE CHARACTERISTICS; IONIZING RADIATION, EXPOSURE; RADIOTHERAPY; CHEMOTHERAPY; ATOM BOMB EXPLOSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Seifert et al., "HPRT-MUTANT FREQUENCY AND LYMPHOCYTE CHARACTERISTICS OF WORKERS EXPOSED TO IONIZING-RADIATION ON A SPORADIC BASIS - A COMPARISON OF 2 EXPOSURE INDICATORS, JOB TITLE AND DOSE", MUTATION RESEARCH, 319(1), 1993, pp. 61-70

Abstract

Using the clonal HPRT-mutant frequency assay, mutant frequencies 'of humans have been shown to rise following exposure to large doses of mutagens during radio therapy, chemotherapy or after an atom bomb explosion. Success in relating mutant frequencies to exposure to high levelsof mutagens has encouraged researchers to examine the effects of lower doses, such as those found among workers exposed at their jobs. In order to relate low doses of mutagens to biological effects, accurate characterization of exposure is critical, but most occupational studiesare forced to use gross measures of exposure derived from job title or professional judgments as to potential exposure. Mutant frequencies and other relevant lymphocyte characteristics of 58 industrial workerswere related to exposure status in two ways. When workers were classed as ''exposed'' or ''unexposed'' to ionizing radiation, no differencein any biological variable was seen between the two groups. When dosimeter readings were used as the exposure indicator, significant relationships appeared between dose and mutant frequency and CD4/CD8 lymphocyte subpopulation ratios. Mutant frequency was also positively relatedto age and smoking status. The time course of exposure and of appearance of mutant cells is discussed, and it is suggested that this relationship receive attention in occupational studies of genotoxic effects.

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Documento generato il 24/09/20 alle ore 05:25:02