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Titolo:
INCREASED PLASMA-LEVELS OF PLATELET-DERIVED GROWTH-FACTOR (PDGF-BB-AB) IN PATIENTS WITH NEVER-TREATED MILD ESSENTIAL-HYPERTENSION(PDGF)
Autore:
ROSSI E; CASALI B; REGOLISTI G; DAVOLI S; PERAZZOLI F; NEGRO A; SANI C; TUMIATI B; NICOLI D;
Indirizzi:
OSPED S MARIA NUOVA,DIV MED INTERNA 2,PADIGL L SPALLANZANI,VIALE UMBERTO I,N 50 I-42100 REGGIO EMILIA ITALY OSPED S MARIA NUOVA,MOL BIOL LAB REGGIO EMILIA ITALY
Titolo Testata:
American journal of hypertension
fascicolo: 10, volume: 11, anno: 1998,
pagine: 1239 - 1243
SICI:
0895-7061(1998)11:10<1239:IPOPG(>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; CHAIN GENE-EXPRESSION; RESISTANCE VESSELS; ANGIOTENSIN-II; RAT AORTA; CELLS; HYPERTROPHY; HYPERPLASIA; RECEPTOR; PRESSURE;
Keywords:
PLATELET-DERIVED GROWTH FACTOR; ESSENTIAL HYPERTENSION; PLATELETS; BETA-THROMBOGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
E. Rossi et al., "INCREASED PLASMA-LEVELS OF PLATELET-DERIVED GROWTH-FACTOR (PDGF-BB-AB) IN PATIENTS WITH NEVER-TREATED MILD ESSENTIAL-HYPERTENSION(PDGF)", American journal of hypertension, 11(10), 1998, pp. 1239-1243

Abstract

Platelet-derived growth factor (PDGF) could play a role in both vascular hypertrophy and atherosclerotic disease associated with hypertension. To assess whether plasma PDGF level is increased in mild essentialhypertension, we measured plasma PDGF concentration in 25 never-treated patients with uncomplicated mild essential hypertension and in 22 normotensive healthy subjects. To evaluate the contribution of platelets to plasma PDGF in the two groups, we also measured plasma beta-thromboglobulin (BTG). Measurement of PDGF was carried out through an enzyme-linked immunoadsorbent assay, which detects two PDGF dimers, namely PDGF-BB and PDGF-AB. Both plasma PDGF and BTG were higher in the hypertensive than in the normotensive subjects. The ratio of PDGF to BTG was similar in the two groups. Plasma PDGF was weakly correlated with plasma BTG in the normotensive subjects, whereas this relationship was lost in the hypertensive patients. Our results suggest that the increase in plasma PDGF (PDGF-AB + PDGF-BB) in never-treated essential hypertension is mainly due to platelet activation. The increased circulatinglevel of PDGF could play a role in the vascular structural changes associated with hypertension. Am J Hypertens 1998; 11:1239-1243 (C) 1998American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:26:31