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Titolo:
LOVASTATIN REDUCES RENAL VASCULAR REACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
JIANG J; SUN CW; ALONSOGALICIA N; ROMAN RJ;
Indirizzi:
MED COLL WISCONSIN,DEPT PHYSIOL,8701 WATERTOWN PLANK RD MILWAUKEE WI 53226 MED COLL WISCONSIN,DEPT PHYSIOL MILWAUKEE WI 53226
Titolo Testata:
American journal of hypertension
fascicolo: 10, volume: 11, anno: 1998,
pagine: 1222 - 1231
SICI:
0895-7061(1998)11:10<1222:LRRVRI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CONTRACTION; ARTERIAL HYPERTROPHY; PROTEIN; CELLS; PROLIFERATION; MEVALONATE; INHIBITION; P21; SHR;
Keywords:
LOVASTATIN; RENAL VASCULAR TONE; SMALL G PROTEINS; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Jiang et al., "LOVASTATIN REDUCES RENAL VASCULAR REACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS", American journal of hypertension, 11(10), 1998, pp. 1222-1231

Abstract

We have reported that lovastatin attenuates the development of hypertension in spontaneously hypertensive rats (SHR). The fall in arterial pressure is associated with an elevation in renal medullary blood flow, normalization of the pressure-natriuresis relationship, and diminished hypertrophy of renal arterioles. However, the mechanism by which lovastatin alters renal vascular tone is unknown. The present study examined the effects of lovastatin on renal vascular tone and the expression of G proteins. Four-week-old SHR were chronically treated with lovastatin (20 mg/kg/day) or vehicle by gavage for 4 weeks. At the end of the study, mean arterial pressure averaged 131 +/- 4 (n = 5) and 160 +/- 4 mm Hg (n 6) in lovastatin- and vehicle-treated SHR, respectively. Renal arterioles isolated from lovastatin-treated SHR were significantly less responsive to norepinephrine and vasopressin than those obtained from vehicle-treated rats (ED50: 5.0 v 1.8 x 10(-7) mol/L for norepinephrine, and 8.0 v 5.2 x 10(-10) mol/L for vasopressin). The fall in renal vascular reactivity in lovastatin-treated SHR was associated with reduced levels of ras and rho proteins in renal arterioles, whereas the expressions of heterotrimeric G proteins (G(s), G(q), G(i)) weresimilar in renal arterioles from vehicle- and lovastatin-treated SHR. Overnight culture of renal arterioles with media containing lovastatin also diminished the expression of ras and rho proteins and the response to vasoconstrictors. These findings indicate that lovastatin diminishes the response to vasoconstrictors and the expression of small G proteins in the renal vasculature of SHR and suggest that a fall in thelevels of ras and rho proteins in these vessels may contribute to theantihypertensive effects of lovastatin. Am J Hypertens 1998;11:1222-1231 (C) 1998 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:45:38