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Titolo:
FATTY-ACID PATTERN OF HUMAN PROSTASOME LIPID
Autore:
ARIENTI G; CARLINI E; POLCI A; COSMI EV; PALMERINI CA;
Indirizzi:
UNIV PERUGIA,IST BIOCHIM & CHIM MED,VIA DEL GIOCHETTO I-06127 PERUGIAITALY UNIV ROMA LA SAPIENZA,DIPARTIMENTO GINECOL & OSTETRICIA I-00161 ROME ITALY UNIV PERUGIA,DIPARTIMENTO BIOL CELLULARE & MOL I-06127 PERUGIA ITALY
Titolo Testata:
Archives of biochemistry and biophysics (Print)
fascicolo: 2, volume: 358, anno: 1998,
pagine: 391 - 395
SICI:
0003-9861(1998)358:2<391:FPOHPL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SEMINAL PLASMA; EXTRACELLULAR ORGANELLES PROSTASOMES; HUMAN-SEMEN; PREVENTS SPERM; MEMBRANE; CHOLESTEROL; PHOSPHOLIPIDS; PROGESTERONE; SPERMATOZOA; VESICLES;
Keywords:
PROSTASOME; SPERM; SEMINAL FLUID; FATTY ACID; GLYCEROLIPID; CHOLESTEROL; MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
G. Arienti et al., "FATTY-ACID PATTERN OF HUMAN PROSTASOME LIPID", Archives of biochemistry and biophysics (Print), 358(2), 1998, pp. 391-395

Abstract

Prostasomes are organelles of prostatic origin found in human semen. Their average diameter is about 150 nm and they appear as a lipoprotein membrane surrounding less organized material. Their lipid composition is peculiar, having much cholesterol and sphingomyelin. On the otherhand, many of their proteins possess catalytic activity and are involved in the immune response. In previous work, we have shown that prostasomes may fuse to sperm at slightly acidic pH values, thereby modifying the composition of the sperm plasma membrane. In this paper, we examine the fatty acid pattern of prostasome lipid and find that it is completely different from that of sperm membrane lipid. Polyunsaturated phosphatidylcholines, common in sperm membrane, are rare in prostasome. Therefore, the fusion between prostasomes and sperm should stabilizesperm plasma membrane by enriching it in cholesterol, sphingomyelin, and saturated glycerophospholipid. This would prevent the untimely occurrence of the acrosome reaction, (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:19:25