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Titolo:
FATTY-ACID DESATURASE ACTIVITIES AND POLYUNSATURATED FATTY-ACID COMPOSITION IN HUMAN LIVER BETWEEN THE 17TH AND 36TH GESTATIONAL WEEKS
Autore:
RODRIGUEZ A; SARDA P; NESSMANN C; BOULOT P; POISSON JP; LEGER CL; DESCOMPS B;
Indirizzi:
FAC MED MONTPELLIER,INST BIOL,LAB BIOL & BIOCHIM LIPIDES,EA DRED 2033,BLVD HENRI 4 F-34060 MONTPELLIER FRANCE FAC MED MONTPELLIER,INST BIOL,LAB BIOL & BIOCHIM LIPIDES F-34060 MONTPELLIER FRANCE HOP ARNAUD VILLENEUVE,SERV PEDIAT 2 VILLENEUVE FRANCE HOP ARNAUD VILLENEUVE,SERV GYNECOL OBSTET VILLENEUVE FRANCE HOP ROBERT DEBRE,SERV BIOL DEV & REPROD PARIS FRANCE UNIV BOURGOGNE,FAC SCI MIRANDE,UPRES LIPIDES & NUTR F-21004 DIJON FRANCE
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 4, volume: 179, anno: 1998,
pagine: 1063 - 1070
SICI:
0002-9378(1998)179:4<1063:FDAAPF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL-ACUITY DEVELOPMENT; ALPHA-LINOLENIC ACID; PRETERM INFANTS; RAT; SUPPLEMENTATION; INTERCONVERSION;
Keywords:
FATTY ACID ANALYSIS; FATTY ACID DESATURASE; HUMAN FETUS; LIVER; MICROSOMES; TIME COURSE RELATIONSHIP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Rodriguez et al., "FATTY-ACID DESATURASE ACTIVITIES AND POLYUNSATURATED FATTY-ACID COMPOSITION IN HUMAN LIVER BETWEEN THE 17TH AND 36TH GESTATIONAL WEEKS", American journal of obstetrics and gynecology, 179(4), 1998, pp. 1063-1070

Abstract

OBJECTIVE: The aim of the study was to characterize n-3 and n-6 fattyacid Delta 5- and Delta 6-desaturase activities and their time coursevariations in human fetal liver between the 17th and 36th gestationalweek. STUDY DESIGN: Twenty-one biologic samples were obtained after legally approved medical abortion, according to French law. The desaturase activities were measured in the 21 liver samples by a radiochemical method by means of reverse-phase high-performance liquid chromatography. The fatty acid composition (percentage by weight) of liver phospholipids was assessed in 16 samples by gas-liquid chromatographic analysis. RESULTS: Both Delta 5- and Delta 6-desaturase activities were significantly expressed between the 17th and 36th gestational weeks. During the second trimester n-6 fatty acid Delta 5- and Delta 6-desaturaseactivities showed opposite patterns of variation; both then remained stable between the 25th and 36th weeks. Delta 6-Desaturation was higher in n-3 than n-6 fatty acids and peaked at the 18th gestational week. The percentages of linoleic and docosahexaenoic acids in liver microsomes were positively correlated with the gestation age (P<.01), whereas arachidonic acid remained stable. CONCLUSION: Significant n-3 and n-6 Delta 5- and Delta 6-desaturase activities are expressed in human fetal liver as early as the 17th gestational week and are stable throughout the third trimester. Their theoretic capacity evaluated from in vitro measurements appears lower than polyunsaturated fatty acid requirements and is not directly related to liver microsomal membrane fatty acid composition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 15:17:56