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Titolo:
SCRATCHING THE (CELL) SURFACE - CYTOKINE ENGINEERING FOR IMPROVED LIGAND RECEPTOR TRAFFICKING DYNAMICS/
Autore:
LAUFFENBURGER DA; FALLON EM; HAUGH JM;
Indirizzi:
MIT,DEPT CHEM ENGN,DIV BIOENGN & ENVIRONM HLTH CAMBRIDGE MA 02139 MIT,CTR BIOMED ENGN CAMBRIDGE MA 02139
Titolo Testata:
Chemistry & biology
fascicolo: 10, volume: 5, anno: 1998,
pagine: 257 - 263
SICI:
1074-5521(1998)5:10<257:ST(S-C>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; RECEPTOR-MEDIATED INTERNALIZATION; HUMAN B-CELLS; INTERLEUKIN-2 RECEPTORS; SIGNAL-TRANSDUCTION; T-LYMPHOCYTES; BETA-CHAIN; POSTENDOCYTIC TRAFFICKING; ENDOSOMAL RETENTION; ENDOCYTIC SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Lauffenburger et al., "SCRATCHING THE (CELL) SURFACE - CYTOKINE ENGINEERING FOR IMPROVED LIGAND RECEPTOR TRAFFICKING DYNAMICS/", Chemistry & biology, 5(10), 1998, pp. 257-263

Abstract

Cytokines can be engineered for greater potency in stimulating cellular functions. An obvious test criterion for an improved cytokine is receptor-binding affinity, but this does not always correlate with improved biological response. By combining protein-engineering techniques with studies of receptor trafficking and signaling, it might be possible to identify the ligand receptor-binding properties that should be sought.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:14:19