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Titolo:
IMMUNOHISTOCHEMICAL LOCALIZATION OF CAFFEINE-INDUCED C-FOS PROTEIN EXPRESSION IN THE RAT-BRAIN
Autore:
BENNETT HJ; SEMBA K;
Indirizzi:
DALHOUSIE UNIV,FAC MED,DEPT ANAT & NEUROBIOL HALIFAX NS B3H 4H7 CANADA DALHOUSIE UNIV,FAC MED,DEPT ANAT & NEUROBIOL HALIFAX NS B3H 4H7 CANADA
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 401, anno: 1998,
pagine: 89 - 108
SICI:
0021-9967(1998)401:1<89:ILOCCP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; INDUCED LOCOMOTOR-ACTIVITY; LOCUS COERULEUS NEURONS; CENTRAL-NERVOUS-SYSTEM; A MESSENGER-RNA; ADENOSINE RECEPTORS; 6-HYDROXYDOPAMINE-LESIONED RATS; PHOSPHODIESTERASE INHIBITORS; COMPARTMENTAL ORGANIZATION; PARAVENTRICULAR NUCLEUS;
Keywords:
ADENOSINE; AROUSAL; CNS STIMULANT; IMMEDIATE-EARLY GENE; XANTHINES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
101
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Bennett e K. Semba, "IMMUNOHISTOCHEMICAL LOCALIZATION OF CAFFEINE-INDUCED C-FOS PROTEIN EXPRESSION IN THE RAT-BRAIN", Journal of comparative neurology, 401(1), 1998, pp. 89-108

Abstract

Although caffeine is the most widely used central nervous system stimulant, the neuronal populations and pathways mediating its stimulant effects are not well understood. Using c-Fos protein as a marker for neuronal activation, the present study investigated the pattern of c-Fosinduction at 2 hours after low locomotor-stimulant doses (1, 5, 10, and 30 mg/kg, i.p.) of caffeine and compared them with those after a higher dose (75 mg/kg, i.p.) or saline injection in adult male rats. Fos-immunoreactive neurons were counted in selected nuclei across the entire brain. Caffeine induced an increase in locomotor activity in a dose-dependent manner up to doses of 30 mg/kg and a decline at 75 mg/kg. Quantitative analysis of Fos-immunoreactive neurons indicated that no structures showed significant Fos expression at doses below 75mg/kg ora biphasic pattern of Fos expression, as in locomotion. In contrast, caffeine at 75 mg/kg induced a significant increase compared with the saline condition in the number of Fos-immunoreactive neurons in the majority of structures examined. The structures included the striatum, nucleus accumbens, globus pallidus, and substantia nigra pars reticulata and autonomic and limbic structures including the basolateral and central nuclei of the amygdala, paraventricular and supraoptic hypothalamic nuclei, periventricular hypothalamus, paraventricular thalamic nuclei, parabrachial nuclei, locus coeruleus, and nucleus of the solitarytract. The locomotor-enhancing effects of low doses of caffeine did not appear to be associated with significant Fos expression in the rat brain. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 28/01/20 alle ore 01:59:26