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Titolo:
ZINC AND ZOLPIDEM MODULATE MIPSCS IN RAT NEOCORTICAL PYRAMIDAL NEURONS
Autore:
DEFAZIO T; HABLITZ JJ;
Indirizzi:
UNIV ALABAMA,DEPT NEUROBIOL BIRMINGHAM AL 35294 UNIV ALABAMA,DEPT NEUROBIOL BIRMINGHAM AL 35294
Titolo Testata:
Journal of neurophysiology
fascicolo: 4, volume: 80, anno: 1998,
pagine: 1670 - 1677
SICI:
0022-3077(1998)80:4<1670:ZAZMMI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORY POSTSYNAPTIC POTENTIALS; GABA(A) RECEPTOR CHANNELS; SUBUNIT MESSENGER-RNAS; GABA(A)-RECEPTOR SUBTYPES; POSTNATAL-DEVELOPMENT; DENTATE GRANULE; MINI AMPLITUDE; BENZODIAZEPINE; BRAIN; PHARMACOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
T. Defazio e J.J. Hablitz, "ZINC AND ZOLPIDEM MODULATE MIPSCS IN RAT NEOCORTICAL PYRAMIDAL NEURONS", Journal of neurophysiology, 80(4), 1998, pp. 1670-1677

Abstract

Pharmacological modulation of gamma-aminobutyric acid-A (GABA(A)) receptors can provide important information on the types of subunits composing these receptors. In recombinant studies, zinc more potently inhibits alpha beta subunits compared with the alpha beta gamma combination, whereas modulation by nanomolar concentrations of the benzodiazepine type 1-selective agonist zolpidem is conferred by the alpha 1 beta gamma 2 subunit combination. We examined four properties of miniature inhibitory postsynaptic currents (mIPSCs) from identified necortical pyramidal cells in rat brain slices: decay time constant, peak amplitude, rate of rise, and interevent interval. Exposure to 50 mu M zinc reduced the decay time constant, peak amplitude, and rate of rise with no effect on interevent interval. Zolpidem enhanced mIPSCs in a concentration-dependent manner. Both 20 and 100 nM zolpidem increased the decaytime constants of mIPSCs. In some cells, both peak amplitude and rateof rise were also enhanced. An cells treated with zinc were also responsive to zolpidem. These results show that neocortical pyramidal cells have a population of GABA, receptors sensitive to both zinc and zolpidem.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 06:59:26