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Titolo:
BONE METABOLISM IN CHILDREN WITH CONGENITAL HYPOTHYROIDISM - A LONGITUDINAL-STUDY
Autore:
VERROTTI A; GRECO R; ALTOBELLI E; MORGESE G; CHIARELLI F;
Indirizzi:
OSPED POLICLIN,COLLE ARA I-66100 CHIETI ITALY UNIV CHIETI,DEPT PEDIAT CHIETI ITALY UNIV SIENA I-53100 SIENA ITALY UNIV AQUILA,DEPT EPIDEMIOL I-67100 LAQUILA ITALY
Titolo Testata:
Journal of pediatric endocrinology & metabolism
fascicolo: 6, volume: 11, anno: 1998,
pagine: 699 - 705
SICI:
0334-018X(1998)11:6<699:BMICWC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLA PROTEIN BGP; THYROID-HORMONES; VITAMIN-D; MINERAL METABOLISM; SERUM; THYROXINE; DENSITY; HYPERTHYROIDISM; REPLACEMENT; CALCITONIN;
Keywords:
CONGENITAL HYPOTHYROIDISM; CALCIUM METABOLISM; VITAMIN-D;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Verrotti et al., "BONE METABOLISM IN CHILDREN WITH CONGENITAL HYPOTHYROIDISM - A LONGITUDINAL-STUDY", Journal of pediatric endocrinology & metabolism, 11(6), 1998, pp. 699-705

Abstract

In order to evaluate the effect of thyroid replacement therapy on bone metabolism in congenital hypothyroid children, we studied 23 (10 girls and 13 boys) consecutive patients, Their age ranged from 3 to 8 weeks. One of these patients had familiar dyshormonogenesis, 21 had ectopic glands and one hemiagenesis, As a control group, we studied 46 sex-and age-matched healthy newborns. Before the beginning of therapy, the hypothyroid patients showed higher values of calcium (2.78 +/- 0.04 vs 2.65 +/- 0.07 mmol/l; p < 0.05) and of 1,25-dihydroxy-vitamin D (159.7 +/- 31.6 vs 90.5 +/- 33.1 ng/l; p < 0.01), while they showed lowervalues of osteocalcin (1.9 +/- 0.8 vs 2.9 +/- 0.9 ng/ml; p < 0.01) than controls, After 3 months of therapy, we found a complete normalization of all these parameters and a progressive increase of osteocalcin. Our data show that in congenital hypothyroid children there are abnormalities in calcium metabolism which seem to be transient and reversible after L-thyroxine replacement therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:50:21