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Titolo:
HEMATOLOGICAL SAFETY OF ANTIPSYCHOTIC-DRUGS
Autore:
KING DJ; WAGER E;
Indirizzi:
QUEENS UNIV BELFAST,DEPT THERAPEUT & PHARMACOL,97 LISBURN RD BELFAST BT9 7BL ANTRIM NORTH IRELAND
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 12, anno: 1998,
pagine: 283 - 288
SICI:
0269-8811(1998)12:3<283:HSOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLOZAPINE-INDUCED AGRANULOCYTOSIS; NEUROLEPTIC MALIGNANT SYNDROME; NEUTROPENIA; RISPERIDONE; RECHALLENGE; MOVEMENT; NEVER; RISK;
Keywords:
ATYPICAL ANTIPSYCHOTICS; HEMATOPOIETIC REACTIONS; POSTMARKETING SURVEILLANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D.J. King e E. Wager, "HEMATOLOGICAL SAFETY OF ANTIPSYCHOTIC-DRUGS", J PSYCHOPH, 12(3), 1998, pp. 283-288

Abstract

Many clinicians have become concerned about the safety of new antipsychotics particularly in view of the association of agranulocytosis with clozapine and of aplastic anaemia with remoxipride. The Committee onSafety of Medicines and Medicines Control Agency 'yellow card' post-marketing surveillance data were analysed for reports of haemopoietic disorders with the 16 antipsychotics in common use. Corrections for relative risk were made in three separate ways: (i) control for degree ofuse, using Northern Ireland prescribing data for 1995; (ii) percentage of total reports from 1963 to 1996; and (iii) examination of the first 5 years' post-marketing data only. After clozapine and remoxipride the highest risks of haemopoietic reactions appeared to be associated with the aliphatic phenothiazine derivatives thioridazine and chlorpromazine. There is therefore no evidence of any increased risk with high-potency drugs such as haloperidol or pimozide or with the newer drugssuch as sulpiride or risperidone. Continued vigilance, however, is necessary as more new atypicals become available and begin to be widely prescribed.

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Documento generato il 25/01/20 alle ore 09:22:32