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Titolo:
ORGANOPHOSPHORUS NEUROPATHY TARGET ESTERASE INHIBITORS SELECTIVELY BLOCK OUTGROWTH OF NEURITE-LIKE AND CELL PROCESSES IN CULTURED-CELLS
Autore:
LI WW; CASIDA JE;
Indirizzi:
UNIV CALIF BERKELEY,DEPT ENVIRONM SCI POLICY & MANAGEMENT,ENVIRONM CHEM & TOXICOL LAB BERKELEY CA 94720 UNIV CALIF BERKELEY,DEPT ENVIRONM SCI POLICY & MANAGEMENT,ENVIRONM CHEM & TOXICOL LAB BERKELEY CA 94720
Titolo Testata:
Toxicology letters
fascicolo: 3, volume: 98, anno: 1998,
pagine: 139 - 146
SICI:
0378-4274(1998)98:3<139:ONTEIS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE; INDUCED DELAYED NEUROTOXICITY; NERVE GROWTH-FACTOR; LINES; RATS; NEUROBLASTOMA; GLIOMA; DAMAGE;
Keywords:
CYTOTOXICITY; MAMMALIAN CELL LINES; NEUROPATHY TARGET ESTERASE; ORGANOPHOSPHORUS COMPOUNDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
W.W. Li e J.E. Casida, "ORGANOPHOSPHORUS NEUROPATHY TARGET ESTERASE INHIBITORS SELECTIVELY BLOCK OUTGROWTH OF NEURITE-LIKE AND CELL PROCESSES IN CULTURED-CELLS", Toxicology letters, 98(3), 1998, pp. 139-146

Abstract

This study compares two direct-acting neuropathy target esterase (NTE) inhibitors (mipafox and 2-octyl-4H-1,3,2-benzodioxophosphorin 2-oxide (OBDPO)), a metabolic precursor to an NTE inhibitor (tri-o-cresyl phosphate or TOCP) and a potent acetylcholinesterase inhibitor (chlorpyrifos oxon or CPO) for their effects on outgrowth of neurite-like and cell processes and on viability in differentiated cultured cells (rat adrenal pheochromocytoma (PC-12) and brain glial tumor (C6)). The direct-acting NTE inhibitors block process outgrowth by 50% or more at 50-100 mu M for OBDPO and 100-200 mu M for mipafox, well below their cytotoxic levels (EC,, values, 445-474 mu M for OBDPO and 1021-1613 mu M for mipafox). In contrast: the effects on process development for TOCP and CPO parallel their cytotoxicity. These findings suggest that inhibition of neurite-like and cell process outgrowth by OBDPO and mipafox may be associated with NTE inhibition. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:45:38