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Titolo:
HERPESVIRUS ENTRY MEDIATOR LIGAND (HVEM-L), A NOVEL LIGAND FOR HVEM TR2, STIMULATES PROLIFERATION OF T-CELLS AND INHIBITS HT29 CELL-GROWTH/
Autore:
HARROP JA; MCDONNELL PC; BRIGHAMBURKE M; LYN SD; MINTON J; TAN KB; DEDE K; SPAMPANATO J; SILVERMAN C; HENSLEY P; DIPRINZIO R; EMERY JG; DEEN K; EICHMAN C; CHABOTFLETCHER M; TRUNEH A; YOUNG PR;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,DEPT MOL BIOL UW2101,709 SWEDELAND RD KING OF PRUSSIA PA 19406 SMITHKLINE BEECHAM PHARMACEUT,DEPT MOL BIOL UW2101 KING OF PRUSSIA PA19406 SMITHKLINE BEECHAM PHARMACEUT,DEPT MOL & CELLULAR IMMUNOL KING OF PRUSSIA PA 19406 SMITHKLINE BEECHAM PHARMACEUT,DEPT BIOL STRUCT KING OF PRUSSIA PA 19406 SMITHKLINE BEECHAM PHARMACEUT,DEPT IMMUNOPHARMACOL KING OF PRUSSIA PA19406 SMITHKLINE BEECHAM PHARMACEUT,DEPT GENE EXPRESS SCI KING OF PRUSSIA PA 19406 SMITHKLINE BEECHAM PHARMACEUT,DEPT PROT BIOCHEM KING OF PRUSSIA PA 19406
Titolo Testata:
The Journal of biological chemistry
fascicolo: 42, volume: 273, anno: 1998,
pagine: 27548 - 27556
SICI:
0021-9258(1998)273:42<27548:HEML(A>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FACTOR RECEPTOR FAMILY; DOMAIN-CONTAINING RECEPTOR; PERIPHERAL LYMPHOID ORGANS; SURFACE-PLASMON RESONANCE; FACTOR-KAPPA-B; DEATH-DOMAIN; MOLECULAR-CLONING; TNF RECEPTOR; TISSUE DISTRIBUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Harrop et al., "HERPESVIRUS ENTRY MEDIATOR LIGAND (HVEM-L), A NOVEL LIGAND FOR HVEM TR2, STIMULATES PROLIFERATION OF T-CELLS AND INHIBITS HT29 CELL-GROWTH/", The Journal of biological chemistry, 273(42), 1998, pp. 27548-27556

Abstract

Herpesvirus entry mediator (HVEM), a member of the tumor necrosis factor (TNF) receptor family, mediates herpesvirus entry into cells during infection. Upon overexpression, HVEM activates NF-kappa B and AP-1 through a TNF receptor-associated factor (TRAF)-mediated mechanism. Using an HVEM-Fc fusion protein, we screened soluble forms of novel TNF-related proteins derived from an expressed sequence fag data base. One of these, which we designated HVEM-L, specifically bound to HVEM-Fc with an affinity of 44 nM. This association was confirmed with soluble and membrane forms of both receptor and ligand, HVEM-L mRNA is expressed in spleen, lymph nodes, macrophages, and T cells and encodes a 240-amino acid protein. A soluble, secreted form of the protein stimulates proliferation of T lymphocytes during allogeneic responses, inhibits HT-29 cell growth, and weakly stimulates NF-kappa B-dependent transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:11:35