Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIVERSIFICATION, EXPRESSION, AND GAMMA-DELTA T-CELL RECOGNITION OF EVOLUTIONARILY DISTANT MEMBERS OF THE MIC FAMILY OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED MOLECULES
Autore:
STEINLE A; GROH V; SPIES T;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,DIV CLIN RES,1100 FAIRVIEW AVE N SEATTLEWA 98109 FRED HUTCHINSON CANC RES CTR,DIV CLIN RES SEATTLE WA 98109
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 21, volume: 95, anno: 1998,
pagine: 12510 - 12515
SICI:
0027-8424(1998)95:21<12510:DEAGTR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPERTOIRE; ANTIGENS; PEPTIDE; INTESTINE; RECEPTOR; LINEAGE; HLA-A2; GENES; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A. Steinle et al., "DIVERSIFICATION, EXPRESSION, AND GAMMA-DELTA T-CELL RECOGNITION OF EVOLUTIONARILY DISTANT MEMBERS OF THE MIC FAMILY OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED MOLECULES", Proceedings of the National Academy of Sciences of the United Statesof America, 95(21), 1998, pp. 12510-12515

Abstract

Distant relatives of major histacompatibility complex (MHC) class I molecules, human MICA and MICB, function as stress-induced antigens that are broadly recognized by intestinal epithelial y delta T cells. They may thus play a central role in the immune surveillance of damaged, infected, or otherwise stressed intestinal epithelial cells. However, the generality of this system in evolution and the mode of recognitionof MICA and MICB are undefined. Analysis of cDNA sequences from various primate species defined translation products that are homologous toMICA and MICB. All of the MIC polypeptides have common characteristics, although they are extraordinarily diverse. The most notable alterations are several deletions and frequent amino acid substitutions in the putative alpha-helical regions of the alpha(1)alpha(2) domains. However, the primate MIC molecules were expressed on the surfaces of normal and transfected cells. Moreover, despite their sharing of relativelyfew identical amino acids in potentially accessible regions of their alpha(1)alpha(2) domains, they were recognized by diverse human intestinal epithelial y delta T cells that are restricted by MICA and MICB. Thus, MIC molecules represent a family of MHC proteins that are structurally diverse yet appear to be functionally conserved. The promiscuous mode of y delta T cell recognition of these antigens may be explained by their sharing of a single conserved interaction site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:38:13