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Titolo:
REQUIREMENT OF G(M2) GANGLIOSIDE ACTIVATOR FOR PHOSPHOLIPASE-D ACTIVATION
Autore:
NAKAMURA S; AKISUE T; JINNAI H; HITOMI T; SARKAR S; MIWA N; OKADA T; YOSHIDA K; KURODA S; KIKKAWA U; NISHIZUKA Y;
Indirizzi:
KOBE UNIV,SCH MED,DEPT BIOCHEM KOBE HYOGO 6500017 JAPAN KOBE UNIV,BIOSIGNAL RES CTR KOBE HYOGO 6578501 JAPAN
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 21, volume: 95, anno: 1998,
pagine: 12249 - 12253
SICI:
0027-8424(1998)95:21<12249:ROGGAF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADP-RIBOSYLATION FACTOR; GTP-BINDING PROTEINS; KINASE-C; ENZYMIC-HYDROLYSIS; RAT-BRAIN; FAMILY; EXPRESSION; SEQUENCE; ARF; PHOSPHORYLATION;
Keywords:
ADP RIBOSYLATION FACTOR PHOSPHATIDYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S. Nakamura et al., "REQUIREMENT OF G(M2) GANGLIOSIDE ACTIVATOR FOR PHOSPHOLIPASE-D ACTIVATION", Proceedings of the National Academy of Sciences of the United Statesof America, 95(21), 1998, pp. 12249-12253

Abstract

Sequence analysis of a heat-stable protein necessary for the activation of ADP ribosylation factor-dependent phospholipase D (PLD) reveals that this protein has a structure highly homologous to the previously known G(M2) ganglioside activator whose deficiency results in the AB-variant of G(M2) gangliosidosis. The heat-stable activator protein indeed has the capacity to enhance enzymatic conversion of G(M2) to G(M3) ganglioside that is catalyzed by beta-hexosaminidase A. Inversely, G(M2) ganglioside activator purified separately from tissues as describedearlier [Conzelmann, E. & Sandhoff, K. (1987) Methods Enzymol, 138, 792-815] stimulates ADP ribosylation factor dependent PLD in a dose-dependent manner. At higher concentrations of ammonium sulfate, the PLD activator protein apparently substitutes for protein kinase C and phosphatidylinositol 4,5-bisphosphate, both of which are known as effectivestimulators of the PLD reaction. The mechanism of action of the heat-stable PLD activator protein remains unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:42:35