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Titolo:
PATTERN OF PRESENTATION OF THE HUMAN GROWTH-HORMONE VARIANT (HGH-V) GENE IN THE NORMAL POPULATION
Autore:
COSTOYA JA; ARCE V; DEVESA J;
Indirizzi:
SCH MED,DEPT PHYSIOL SANTIAGO COMPOSTE 15705 SPAIN
Titolo Testata:
Journal of pediatric endocrinology & metabolism
fascicolo: 5, volume: 11, anno: 1998,
pagine: 591 - 595
SICI:
0334-018X(1998)11:5<591:POPOTH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC SOMATOMAMMOTROPIN; DEFICIENCY; DELETION; CLUSTER; GH; MUTATIONS; PREGNANCIES; RETARDATION; EVOLUTION; ABSENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Costoya et al., "PATTERN OF PRESENTATION OF THE HUMAN GROWTH-HORMONE VARIANT (HGH-V) GENE IN THE NORMAL POPULATION", Journal of pediatric endocrinology & metabolism, 11(5), 1998, pp. 591-595

Abstract

The human growth hormone variant (hGH-V) gene is a member of the GH gene family, expressed by the syncytiotrophoblast. Although its physiological role is poorly understood, certain data suggest that it may be involved in the control of fetal growth and development. As a first step to asses its physiological relevance, we investigated its degree ofpolymorphism in the normal population. Genetic studies have been difficult to carry out due to the high sequence identity among GH-family members. We overcame this problem by selectively amplifying a fragment of the hGH-V gene by PCR, DSCP analysis of the amplimers revealed a heterozygous pattern in one of the 64 subjects studied. Investigation ofthe subject's relatives showed a similar pattern in his father. In all, our results indicate that the hGH-V gene is highly conserved in thenormal population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:53:04