Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PSEUDO-EXCLUSION FROM PATERNITY DUE TO MATERNAL UNIPARENTAL DISOMY-16
Autore:
BEIN G; DRILLER B; SCHURMANN M; SCHNEIDER PM; KIRCHNER H;
Indirizzi:
UNIV GIESSEN,INST CLIN IMMUNOL & TRANSFUS MED,LANGHANSSTR 7 D-35392 GIESSEN GERMANY UNIV LUBECK,SCH MED,INST IMMUNOL & TRANSFUS MED D-2400 LUBECK GERMANY UNIV LUBECK,SCH MED,INST HUMAN GENET D-2400 LUBECK GERMANY UNIV MAINZ,INST MED LEGALE D-6500 MAINZ GERMANY
Titolo Testata:
International journal of legal medicine
fascicolo: 6, volume: 111, anno: 1998,
pagine: 328 - 330
SICI:
0937-9827(1998)111:6<328:PFPDTM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROBE MZ 1.3; DNA; HUMANS;
Keywords:
UNIPARENTAL DISOMY; UPD CHROMOSOME 16; PARENTAGE TESTING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
G. Bein et al., "PSEUDO-EXCLUSION FROM PATERNITY DUE TO MATERNAL UNIPARENTAL DISOMY-16", International journal of legal medicine, 111(6), 1998, pp. 328-330

Abstract

The investigation of a case of disputed paternity revealed indirect exclusion of the alleged father in the haptoglobin system and in the DNA single-locus system D16S309/Hinf I (MS205). The paternity index for the non-exclusion systems was > 10(6). Since both exclusion systems (HP and MS205) are located on chromosome 16, we investigated 10 microsntellite loci covering this chromosome with 10-20 cM resolution. Analysis of the child's chromosome showed only alleles of maternal origin andlack of inheritance of paternal alleles for five informative loci. The markers close to die centromere of chromosome 16 were heterozygous, whereas distal loci were either heterozygous or homozygous for maternal alleles. This is consistent with a maternal meiosis I nondisjunctionof chromosome 16 leading to maternal uniparental heterodisomy. This case emphasizes that the opinion of non-paternity should be based on the absence of paternal alleles at genetic systems located on at least two different chromosomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:47:53