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Titolo:
EXAMINATION OF THE RELATIONSHIPS BETWEEN JAW OPENER AND CLOSER RHYTHMICAL MUSCLE-ACTIVITY IN AN IN-VITRO BRAIN-STEM JAW-ATTACHED PREPARATION
Autore:
KOGO M; TANAKA S; CHANDLER SH; MATSUYA T;
Indirizzi:
OSAKA UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG 1,1-8 YAMADAOKA SUITA OSAKA 565 JAPAN UNIV CALIF LOS ANGELES,DEPT PHYSIOL SCI LOS ANGELES CA 00000
Titolo Testata:
Somatosensory & motor research
fascicolo: 3, volume: 15, anno: 1998,
pagine: 200 - 210
SICI:
0899-0220(1998)15:3<200:EOTRBJ>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED GUINEA-PIG; RAT SPINAL-CORD; IN-VITRO; NEONATAL RAT; INTRACELLULAR ANALYSIS; MASTICATORY RHYTHM; RESPIRATORY RHYTHM; PATTERN GENERATOR; MOTOR-ACTIVITY; CHICK-EMBRYO;
Keywords:
ORAL-MOTOR; FEEDING; JAW MOVEMENTS; SUCKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Kogo et al., "EXAMINATION OF THE RELATIONSHIPS BETWEEN JAW OPENER AND CLOSER RHYTHMICAL MUSCLE-ACTIVITY IN AN IN-VITRO BRAIN-STEM JAW-ATTACHED PREPARATION", Somatosensory & motor research, 15(3), 1998, pp. 200-210

Abstract

An in vitro jaw-attached brainstem preparation was developed to investigate the relationship between jaw opener and closer muscle activity during chemically induced rhythmical jaw movements in neonatal rats. In the majority of preparations examined, where a defined region of brainstem was isolated and the neuronal innervation of the jaw opener andcloser muscles was left intact, bath application of the excitatory amino acid agonist N-methyl-D,L-aspartate (NMA, 20-40 mu M) in combination with bicuculline (BIC 10 mu M), a GABA(A) antagonist, produced rhythmical electromyogram (EMG) activity in jaw opener and closer muscles,bilaterally, in conjunction with rhythmical jaw movements. Low concentrations of NMA (20 mu M) in combination with BIC produced temporally coordinated activity between the jaw opener and closer muscles, ipsilaterally. With higher doses of NMA (40 mu M), each muscle group exhibited bursting, but temporal coordination between them was difficult to establish. Similarly, NMA application in combination with the glycine antagonist strychnine (STR, 10 mu M), also produced rhythmical EMG activity from both opener and closer muscles, ipsilaterally, but showed notemporal coordination between the antagonist muscle pair. However, coordination of opener and closer muscle discharge could be restored by the addition of BIC to the bath. We suggest that there exist separate,but coordinated, rhythm generator circuits for opener and closer motoneuronal discharge located in close proximity to the trigeminal motor nucleus and under GABAergic control for production of temporal coordination between rhythmogenic circuits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:17:58