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Titolo:
INTRAEPITHELIAL NERVE-FIBERS IN THE NASAL-MUCOSA OF THE RAT WITH SPECIAL REFERENCE TO THE LOCALIZATION OF CGRP, VIP AND NITRIC-OXIDE (NO)
Autore:
LEE SH; IWANAGA T; FUJITA T;
Indirizzi:
KOREA UNIV,ANAM HOSP,COLL MED,DEPT OTOLARYNGOL HEAD & NECK SURG,SUNGBUK KU,126-1,5 KA ANAM DONG SEOUL 136705 SOUTH KOREA NIIGATA UNIV,SCH MED,DEPT ANAT NIIGATA 951 JAPAN
Titolo Testata:
Archives of histology and cytology
fascicolo: 4, volume: 58, anno: 1995,
pagine: 449 - 456
SICI:
0914-9465(1995)58:4<449:INITNO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED-PEPTIDE; SUBSTANCE-P; NADPH-DIAPHORASE; CO-EXISTENCE; ULTRASTRUCTURE; NEUROPEPTIDE; INNERVATION; EPITHELIUM; SYNTHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Lee et al., "INTRAEPITHELIAL NERVE-FIBERS IN THE NASAL-MUCOSA OF THE RAT WITH SPECIAL REFERENCE TO THE LOCALIZATION OF CGRP, VIP AND NITRIC-OXIDE (NO)", Archives of histology and cytology, 58(4), 1995, pp. 449-456

Abstract

Previous studies have demonstrated that the epithelium of the respiratory portion of rat nasal mucosa is amply supplied by nerve fibers with immunoreactivities for calcitonin gene-related peptide (CGRP) and substance P (SP), these fibers most likely acting as sensory mediators in the mucosa. The present study demonstrates that some intraepithelialfibers contain a VIP-immunoreactivity whose occurrence in these nerves has previously been neglected. The present study further aims to confirm the occurrence of NO-producing intraepithelial nerve fibers in the rat nasal mucosa and to examine its colocalization with CGRP and with VIP. Double staining methods were used to evaluate the colocalization of NADPH-diaphorase reactivity and CGRP- or VIP-immunoreactivity. The reactivity for NADPH-diaphorase and that for CGRP coexisted in only a small part, if any, of the nerve fibers distributed at the basal portion of the epithelium. In the perpendicularly and obliquely oriented transepithelial nerve fibers, both reactivities were clearly demonstrated to be separated in different fibers. VIP immunoreactivity was alsopresent in a part of the intraepithelial nerve fibers of the nasal mucosa, and their entire population was shown to be positive for NADPH-diaphorase. The NADPH-diaphorase-positive reaction was displayed in only a small population of neurons in the trigeminal ganglion, whereas itwas seen in numerous neurons in sphenopalatine ganglion, being colocalized with VIP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:02:01