Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CELL-DEATH INDUCED BY TOPOISOMERASE-TARGETED DRUGS - MORE QUESTIONS THAN ANSWERS
Autore:
KAUFMANN SH;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV ONCOL RES,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO GRAD SCH MED,DEPT PHARMACOL ROCHESTER MN 55905
Titolo Testata:
Biochimica et biophysica acta, N. Gene structure and expression
fascicolo: 1-3, volume: 1400, anno: 1998,
pagine: 195 - 211
SICI:
0167-4781(1998)1400:1-3<195:CIBTD->2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOTHERAPY-INDUCED APOPTOSIS; DNA-DAMAGING AGENTS; ETOPOSIDE-INDUCED APOPTOSIS; ICE/CED-3 FAMILY PROTEASES; DEPENDENT PROTEIN-KINASE; TUMOR-NECROSIS-FACTOR; ENZYME-LIKE PROTEASES; HAMSTER OVARY CELLS; ICE-LIKE PROTEASES; CYTOCHROME-C;
Keywords:
DNA TOPOISOMERASE; APOPTOSIS; CASPASE; ETOPOSIDE; CAMPTOTHECIN; TOPOISOMERASE; MUTATION; DNA REPAIR; PHOSPHATASE; APOPTOSIS; CASPASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
185
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Kaufmann, "CELL-DEATH INDUCED BY TOPOISOMERASE-TARGETED DRUGS - MORE QUESTIONS THAN ANSWERS", Biochimica et biophysica acta, N. Gene structure and expression, 1400(1-3), 1998, pp. 195-211

Abstract

Chemotherapeutic agents that target topoisomerase I and II set into motion a series of biochemical changes that culminate in cell death, but only under some conditions. The realization that stabilization of covalent topoisomerase-DNA complexes is not sufficient to insure cell death has prompted investigators to examine various aspects of the drug-induced death process itself. Several discrete steps along this pathway have been identified, including (a) the processing of stabilized cleavage complexes into frank DNA strand breaks; (b) sensing of the DNA damage, leading to activation of stress-associated signaling pathways and cell cycle arrest; and (c) activation of a preexisting group of enzymes and enzyme precursors, typified by the cysteine-dependent aspartate-directed proteases (caspases), that catalyze the relatively orderlybiochemical cascade of terminal events known as apoptosis. The present review discusses the evidence that these steps occur after treatmentwith etoposide or camptothecin, the two prototypic topoisomerase poisons that are commonly studied. As in any emerging area, a large numb er of questions remain to be answered ab out the process of cell death induced by topoisomerase-directed drugs. 0167-4781/98/$ - see front matter (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:27:46