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Titolo:
DEVELOPMENTAL TOXICITY OF D-002 (A MIXTURE OF ALIPHATIC PRIMARY ALCOHOLS) IN RATS AND RABBITS
Autore:
RODRIGUEZ MD; GAMEZ R; SANCHEZ M; GARCIA H;
Indirizzi:
NATL CTR SCI RES,DEPT TOXICOL,POB 6880 HAVANA CUBA
Titolo Testata:
Journal of applied toxicology
fascicolo: 5, volume: 18, anno: 1998,
pagine: 313 - 316
SICI:
0260-437X(1998)18:5<313:DTOD(M>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEESWAX;
Keywords:
DEVELOPMENTAL TOXICITY; RAT; RABBIT; POLICOSANOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Rodriguez et al., "DEVELOPMENTAL TOXICITY OF D-002 (A MIXTURE OF ALIPHATIC PRIMARY ALCOHOLS) IN RATS AND RABBITS", Journal of applied toxicology, 18(5), 1998, pp. 313-316

Abstract

D-002 is a mixture of higher aliphatic alcohols, primarily isolated and purified from beeswax, that has moderate anti-inflammatory and effective anti-ulcer activity, In the present study the developmental toxicity in Sprague-Dawley rats and New Zealand White rabbits was evaluated. Doses of 100, 320 and 1000 mg kg(-1) were administered once daily by gavage to pregnant females on gestation days 6-15 (rats) or 6-18 (rabbits). Reproductive indices were determined and foetuses were examined for external, visceral and skeletal malformations, There was no indication of embryotoxicity, fetotoxicity or teratogenicity in any of thetreated groups, It is concluded that D-002 is devoid of teratogenic or embryotoxic effects in these strains, (C) 1998 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:32:44