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Titolo:
MELATONINS ROLE AS AN ANTICONVULSANT AND NEURONAL PROTECTOR - EXPERIMENTAL AND CLINICAL-EVIDENCE
Autore:
MUNOZHOYOS A; SANCHEZFORTE M; MOLINACARBALLO A; ESCAMES G; MARTINMEDINA E; REITER RJ; MOLINAFONT JA; ACUNACASTROVIEJO D;
Indirizzi:
UNIV GRANADA,FAC MED,DEPT PEDIAT,AVDA MADRID 12 E-18071 GRANADA SPAIN UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL SAN ANTONIO TX 78284 UNIV GRANADA,INST BIOTECNOL,DEPT FISIOL E-18071 GRANADA SPAIN
Titolo Testata:
Journal of child neurology
fascicolo: 10, volume: 13, anno: 1998,
pagine: 501 - 509
SICI:
0883-0738(1998)13:10<501:MRAAAA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 FLUNITRAZEPAM BINDING; AMINO-ACID RECEPTORS; RAT CEREBRAL-CORTEX; PINEAL-GLAND; QUINOLINIC ACID; KYNURENIC ACID; PHOTOPAROXYSMAL RESPONSE; BENZODIAZEPINE BINDING; EPILEPTIC CONVULSIONS; SEASONAL-VARIATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
111
Recensione:
Indirizzi per estratti:
Citazione:
A. Munozhoyos et al., "MELATONINS ROLE AS AN ANTICONVULSANT AND NEURONAL PROTECTOR - EXPERIMENTAL AND CLINICAL-EVIDENCE", Journal of child neurology, 13(10), 1998, pp. 501-509

Abstract

The pineal gland classically has been considered as a vestigial and mystic organ. In the last decades, and with the incorporation of new methodologic procedures, it could be proved that it also has physiologicactions that vary depending on the level of the phylogenetic scale. Its best-known secretion, melatonin, has been related to many differentactions, such as sleep promotion, control of biologic rhythms, hormonal inhibition, and an inhibiting action on central nervous system regulation mechanisms. In animal experimentation, there are papers even accepting an anticonvulsant effect. In humans, evidence is reduced to few experiences. In addition to this clinical experience, there is otherevidence that clearly relates melatonin to convulsive phenomena. Thisrelationship must be mediated by the following mechanisms attributed to melatonin: altered brain GABAergic neurotransmission, its known interaction with benzodiazepinic brain receptors, through tryptophan metabolite activity (kynurenine, kynurenic acid), or even by its efficacy as a free-radical scavenger.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:13:20