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Titolo:
RENAL EXCRETORY RESPONSES PRODUCED BY THE DELTA-OPIOID AGONIST, BW373U86, IN CONSCIOUS RATS
Autore:
SEZEN SF; KENIGS VA; KAPUSTA DR;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL,1901 PERDIDO ST NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL & EXPT THERAPEUT NEW ORLEANS LA 70112
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 287, anno: 1998,
pagine: 238 - 245
SICI:
0022-3565(1998)287:1<238:RERPBT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; SPONTANEOUSLY HYPERTENSIVE RATS; DIURETIC ACTION; VASOPRESSIN; EXPRESSION; MORPHINE; NERVES; MU; NALTRINDOLE; ENKEPHALIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Sezen et al., "RENAL EXCRETORY RESPONSES PRODUCED BY THE DELTA-OPIOID AGONIST, BW373U86, IN CONSCIOUS RATS", The Journal of pharmacology and experimental therapeutics, 287(1), 1998, pp. 238-245

Abstract

Studies were performed in conscious Sprague-Dawley rats to characterize the changes in renal excretory function produced by activation of delta opioid systems. The intravenous infusion of 50 mu g/kg/min, BW373U86 (BW), a nonpeptide delta opioid receptor agonist, produced a significant increase in urine flow rate and urinary sodium excretion. The infusion of BW at a dose of 30 mu g/kg/min produced diuresis without affecting urinary sodium excretion. In contrast, BW did not alter eitherrenal excretory parameter at a dose of 10 mu g/kg/min. The renal responses produced by BW occurred without changes in heart rate or mean arterial blood pressure. The diuretic and natriuretic responses producedby the i.v. infusion of BW (50 mu g/kg/min) were prevented by pretreatment of animals with the selective delta opioid receptor antagonist, naltrindole (1 mg/kg, i.v.). When administered alone, naltrindole (1 mg/kg, i.v.) failed to change any systemic cardiovascular or renal excretory parameter. In other groups of animals, the peripheral administration of the delta opioid receptor agonist, SNC80, also evoked a profound diuretic and natriuretic response (naltrindole sensitive) similar to that produced by BW. In contrast to these findings, the diuretic andnatriuretic response produced by BW infusion (30 or 50 mu g/kg/min, i.v.) was abolished in rats having undergone chronic bilateral renal denervation. Together, these results demonstrate that the peripheral administration of BW373U86 or SNC80 produce marked diuretic and natriuretic responses in conscious Sprague-Dawley rats via a delta opioid receptor pathway and that intact renal nerves are required for mediating these responses. Although endogenous delta opioid systems do not appear to exert a tonic influence under basal conditions, these findings suggest that delta opioid pathways may evoke significant changes in renal excretory function under conditions in which these systems are activated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:11:45